The prospects for Near Infrared (NIR) spectroscopy and imaging of the breast for detection, characterization, and monitoring of disease continue to appear promising. The technology is particularly attractive in this setting because it offers low-cost, non-ionizing exposures, very high intrinsic contrast for'pathology and images of functional information associated with physiological and compositional tissue changes. During the current funding period Project IV, Near Infrared Spectroscopy and Imaging, has realized an NIR,imaging system that creates quantitative maps of hemoglobin concentration, oxygen saturation, water content and scattering parameters in vivo. The system is clinically operational, collects three-dimensional, multi-spectral optical data and produces two and three-dimensional images of the breast volume of interest. It has been used to deliver well over 100 clinical exams ? data which has been analyzed to (i) establish normative responses in breasts without disease (ii) explore optical property variations with menstrual cycle and changes in breast compression at time of exam, (iii) estimate NIR image contrast in breasts with screening abnormalities, and (iv) correlate NIR imaged parameters with pathological markers identified through histology. The proposal for continuation of Project IV builds on this foundation in several significant ways through a research plan that consists of both technical and clinical advances. Technically, it will extend the spectroscopy and imaging systems available through incorporation of both hardware and software based coregistrations with MR (Magnetic Resonance) and wideband spectral acquisitions through both full-field optical arrays and localized point spectroscopy probes. Clinical involvement will not only include continued NIR imaging of screening abnormalities recommended for biopsy but also extend to larger palpable masses on clinical breast exams and locally advanced breast cancers receiving neoadjuvant therapy, the long-term goal of this research is to determine the likely role of NIR breast imaging for risk assessment, early detection, differential diagnosis, treatment prognosis and therapy monitoring, It is expected that sufficient evidence will be generated during the requested funding period to allow convincing estimates of the potential of NIR breast imaging as an alternative for differential diagnosis, and pilot data in support of a role in treatment prognosis and therapy monitoring which would inform decisions on the initiation of multi-center trials with the technology in the future.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA080139-09
Application #
7826811
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2009-05-01
Budget End
2010-04-30
Support Year
9
Fiscal Year
2009
Total Cost
$172,044
Indirect Cost
Name
Dartmouth College
Department
Type
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Halter, Ryan J; Hartov, Alex; Poplack, Steven P et al. (2015) Real-time electrical impedance variations in women with and without breast cancer. IEEE Trans Med Imaging 34:38-48
Epstein, N R; Meaney, P M; Paulsen, K D (2014) 3D parallel-detection microwave tomography for clinical breast imaging. Rev Sci Instrum 85:124704
Jiang, Shudong; Pogue, Brian W; Kaufman, Peter A et al. (2014) Predicting breast tumor response to neoadjuvant chemotherapy with diffuse optical spectroscopic tomography prior to treatment. Clin Cancer Res 20:6006-15
Meaney, Paul M; Kaufman, Peter A; Muffly, Lori S et al. (2013) Microwave imaging for neoadjuvant chemotherapy monitoring: initial clinical experience. Breast Cancer Res 15:R35
Laughney, Ashley M; Krishnaswamy, Venkataramanan; Rice, Tyler B et al. (2013) System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues. J Biomed Opt 18:036012
Krishnaswamy, Venkataramanan; Laughney, Ashley M; Wells, Wendy A et al. (2013) Scanning in situ spectroscopy platform for imaging surgical breast tissue specimens. Opt Express 21:2185-94
Jiang, Shudong; Pogue, Brian W; Michaelsen, Kelly E et al. (2013) Pilot study assessment of dynamic vascular changes in breast cancer with near-infrared tomography from prospectively targeted manipulations of inspired end-tidal partial pressure of oxygen and carbon dioxide. J Biomed Opt 18:76011
Laughney, Ashley M; Krishnaswamy, Venkataramanan; Rizzo, Elizabeth J et al. (2013) Spectral discrimination of breast pathologies in situ using spatial frequency domain imaging. Breast Cancer Res 15:R61
Meaney, Paul M; Goodwin, Douglas; Golnabi, Amir H et al. (2012) Clinical microwave tomographic imaging of the calcaneus: a first-in-human case study of two subjects. IEEE Trans Biomed Eng 59:3304-13
Grzegorczyk, Tomasz M; Meaney, Paul M; Kaufman, Peter A et al. (2012) Fast 3-d tomographic microwave imaging for breast cancer detection. IEEE Trans Med Imaging 31:1584-92

Showing the most recent 10 out of 129 publications