The principle function of this laboratory is to provide mass spectrometry analysis for the investigators participating in the program project. Specifically this Core will perform qualitative and quantitative analysis of phospholipid subclasses and molecular species of these subclasses using state-of-the-art electrospray tandem mass spectrometry (ESI/MS/MS). In addition, the facility will quantify 5-HETE, PGE2, and other oxidized polyunsaturated fatty acids generated by tissue culture samples. The source of the samples will be from tissue culture and tissue collected from animal models. The sensitivity and dynamic range of the methodology can measure from pmole to fmole amounts of lipid. As required, the Core will implement and develop advanced methodologies to facilitate the analysis of lipids for the program project.
| Suburu, Janel; Shi, Lihong; Wu, Jiansheng et al. (2014) Fatty acid synthase is required for mammary gland development and milk production during lactation. Am J Physiol Endocrinol Metab 306:E1132-43 |
| Wang, Mingxuan; Chen, Haiqin; Gu, Zhennan et al. (2013) ?3 fatty acid desaturases from microorganisms: structure, function, evolution, and biotechnological use. Appl Microbiol Biotechnol 97:10255-62 |
| O'Flaherty, Joseph T; Wooten, Rhonda E; Samuel, Michael P et al. (2013) Fatty acid metabolites in rapidly proliferating breast cancer. PLoS One 8:e63076 |
| Suburu, Janel; Gu, Zhennan; Chen, Haiqin et al. (2013) Fatty acid metabolism: Implications for diet, genetic variation, and disease. Food Biosci 4:1-12 |
| Chen, Haiqin; Gu, Zhennan; Zhang, Hao et al. (2013) Expression and purification of integral membrane fatty acid desaturases. PLoS One 8:e58139 |
| Chen, Yong Q (2013) Cancer and Metastasis Reviews. Introduction. Cancer Metastasis Rev 32:3-4 |
| Gu, Zhennan; Wu, Jiansheng; Wang, Shihua et al. (2013) Polyunsaturated fatty acids affect the localization and signaling of PIP3/AKT in prostate cancer cells. Carcinogenesis 34:1968-75 |
| Hu, Yunping; Sun, Haiguo; O'Flaherty, Joseph T et al. (2013) 15-Lipoxygenase-1-mediated metabolism of docosahexaenoic acid is required for syndecan-1 signaling and apoptosis in prostate cancer cells. Carcinogenesis 34:176-82 |
| Suburu, Janel; Chen, Yong Q (2012) Lipids and prostate cancer. Prostaglandins Other Lipid Mediat 98:1-10 |
| Conley-LaComb, M Katie; Huang, Wei; Wang, Shihua et al. (2012) PTEN regulates PDGF ligand switch for ?-PDGFR signaling in prostate cancer. Am J Pathol 180:1017-27 |
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