The overall purpose of Core A is to provide administrative support to the projects and cores of the Program, which enable the Program as a whole to meet its scientific mission more efficiently and expeditiously. The Core achieves this by carrying out a number of specific functions that relieve PIs of administrative concerns and enhance the coordination of work within the Program and the productive interaction ofthe Program with the larger research community. These functions will include:
Aim 1 : To ensure that the work carried out under the auspices of this Program meet the requirements of the NCI and NIH Aim 2: To coordinate meetings among the Program investigators and their laboratories Aim 3: To provide financial accounting to the PI and Project Leaders of each project and core.
Aim 4 : To coordinate communication between the investigators of the Program and Scientific Advisory Board.
Aim 5 : To coordinate travel related to the Program for the investigators and facilitate submission of manuscripts emanating from Program activities.
Aim 6 : To communicate the work emanating from our Program to the wider scientific community.

Public Health Relevance

The Administration Core plays an essential support role for all of the scientific projects of the Program, which are focused on understanding how Notch receptors are activated and turn on the expression of genes that drive the growth and survival of cancer cells. Thus, this shared resource is critical for the success of studies designed to elucidate fundannental aspects of how Notch signaling causes cancer, which in turn is likely to lead to new diagnostic approaches and therapies.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA119070-07
Application #
8558600
Study Section
Special Emphasis Panel (ZCA1-RPRB-J)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
7
Fiscal Year
2013
Total Cost
$35,334
Indirect Cost
$14,590
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Johnson, John L; Georgakilas, Georgios; Petrovic, Jelena et al. (2018) Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells. Immunity 48:243-257.e10
Jiang, Peng; Lee, Winston; Li, Xujuan et al. (2018) Genome-Scale Signatures of Gene Interaction from Compound Screens Predict Clinical Efficacy of Targeted Cancer Therapies. Cell Syst 6:343-354.e5
Severson, Eric; Arnett, Kelly L; Wang, Hongfang et al. (2017) Genome-wide identification and characterization of Notch transcription complex-binding sequence-paired sites in leukemia cells. Sci Signal 10:
Ryan, Russell J H; Petrovic, Jelena; Rausch, Dylan M et al. (2017) A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas. Cell Rep 21:784-797
McMillan, Brian J; Tibbe, Christine; Drabek, Andrew A et al. (2017) Structural Basis for Regulation of ESCRT-III Complexes by Lgd. Cell Rep 19:1750-1757
Pajcini, Kostandin V; Xu, Lanwei; Shao, Lijian et al. (2017) MAFB enhances oncogenic Notch signaling in T cell acute lymphoblastic leukemia. Sci Signal 10:
Sajed, Dipti P; Faquin, William C; Carey, Chris et al. (2017) Diffuse Staining for Activated NOTCH1 Correlates With NOTCH1 Mutation Status and Is Associated With Worse Outcome in Adenoid Cystic Carcinoma. Am J Surg Pathol 41:1473-1482
Aster, Jon C; Pear, Warren S; Blacklow, Stephen C (2017) The Varied Roles of Notch in Cancer. Annu Rev Pathol 12:245-275
Seegar, Tom C M; Killingsworth, Lauren B; Saha, Nayanendu et al. (2017) Structural Basis for Regulated Proteolysis by the ?-Secretase ADAM10. Cell 171:1638-1648.e7
Stein, Sarah J; Mack, Ethan A; Rome, Kelly S et al. (2016) Trib2 Suppresses Tumor Initiation in Notch-Driven T-ALL. PLoS One 11:e0155408

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