In collaboration with The Ohio State University (OSU;Project 1;Cores B and D), the University of Illinois at Chicago (UIC;Project 2;Core A), and Research Triangle Institute (RTI;Project 3), in Core C Bristol-Myers Squibb (B-MS) plans to identify and evaluate novel anticancer agents derived from various natural product sources (plants, terrestrial cyanobacteria, and filamentous fungi). The Pharmaceutical Research Institute of B-MS is part of one of the largest pharmaceutical companies in the world, with a strong commitment to, dedicated resources for, and a proven track record in natural product drug discovery and development. With respect to this project, we plan to carry out the following Specific Aims: 1. Assay crude and semi-purified extracts as well as isolated pure compounds for cytotoxic and/or cytostatic activity in a diverse tumor cell line panel to aid the discovery of novel anticancer agents. 2. Assay crude and semi-purified extracts as well as isolated pure compounds in various molecular mechanism based/target-driven oncology screens to aid in the identification of novel, targeted anticancer agents. 3. Support activity-guided fractionation of the active constituents either by performing the assays at B-MS or transferring the high throughput screen (HTS) technology to our collaborators. 4. Assist in the selection and prioritization of the biologically most relevant leads. 5. Characterize leads in their appropriate cellular assays. 6. Provide broad preclinical development support including pharmacology, chemistry, toxicology, pharmacokinetics, and pharmaceutics, for compounds matching the preclinical lead profile criteria of B-MS. 7. Advance compounds to IND submission and clinical development, if warranted.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Ohio State University
United States
Zip Code
May, Daniel S; Kang, Hahk-Soo; Santarsiero, Bernard D et al. (2018) Ribocyclophanes A-E, Glycosylated Cyclophanes with Antiproliferative Activity from Two Cultured Terrestrial Cyanobacteria. J Nat Prod 81:572-578
Oblinger, Janet L; Burns, Sarah S; Huang, Jie et al. (2018) Overexpression of eIF4F components in meningiomas and suppression of meningioma cell growth by inhibiting translation initiation. Exp Neurol 299:299-307
Amrine, Chiraz Soumia M; Raja, Huzefa A; Darveaux, Blaise A et al. (2018) Media studies to enhance the production of verticillins facilitated by in situ chemical analysis. J Ind Microbiol Biotechnol 45:1053-1065
Young, Alexandria N; Herrera, Denisse; Huntsman, Andrew C et al. (2018) Phyllanthusmin Derivatives Induce Apoptosis and Reduce Tumor Burden in High-Grade Serous Ovarian Cancer by Late-Stage Autophagy Inhibition. Mol Cancer Ther 17:2123-2135
Acuña, Ulyana Muñoz; Mo, Shunyan; Zi, Jiachen et al. (2018) Hapalindole H Induces Apoptosis as an Inhibitor of NF-?B and Affects the Intrinsic Mitochondrial Pathway in PC-3 Androgen-insensitive Prostate Cancer Cells. Anticancer Res 38:3299-3307
Al-Huniti, Mohammed H; Rivera-Chávez, José; Colón, Katsuya L et al. (2018) Development and Utilization of a Palladium-Catalyzed Dehydration of Primary Amides To Form Nitriles. Org Lett 20:6046-6050
Crnkovic, Camila M; Krunic, Aleksej; May, Daniel S et al. (2018) Calothrixamides A and B from the Cultured Cyanobacterium Calothrix sp. UIC 10520. J Nat Prod 81:2083-2090
Wilson, Tyler A; Tokarski 2nd, Robert J; Sullivan, Peter et al. (2018) Total Synthesis of Scytonemide A Employing Weinreb AM Solid-Phase Resin. J Nat Prod 81:534-542
Lu, Chunwan; Yang, Dafeng; Sabbatini, Maria E et al. (2018) Contrasting roles of H3K4me3 and H3K9me3 in regulation of apoptosis and gemcitabine resistance in human pancreatic cancer cells. BMC Cancer 18:149
El-Elimat, Tamam; Rivera-Chávez, José; Burdette, Joanna E et al. (2018) Cytotoxic homoisoflavonoids from the bulbs of Bellevalia flexuosa. Fitoterapia 127:201-206

Showing the most recent 10 out of 144 publications