The responsibility ofthe Administrative Core will be to ensure that the program project grant operates smoothly. The Core is directed by Dr. Hecht as Principal Invesfigator of the program project grant. Four committees have been organized to assist with the successful operation of the Administrafive Core. They are the Steering Committee, the Internal Advisory Committee, the External Advisory Committee, and the Results Disseminafion and Policy Committee. The Steering Committee will meet monthly and will discuss and evaluate progress in all projects and cores, and plan new directions as necessary. It will establish priorifies, coordinate data, and manage reports, publicafions, and problem areas. The Internal Advisory Committee will meet annually and will be responsible for keeping other units ofthe participafing universifies informed of progress as necessary and for solving any administrafive problems regarding the relafionship of this research to that in other university units. The External Advisory Committee will meet annually and will be responsible for advising program project members on their research and helping in the interpretation of data and planning of new studies as necessary. The Results Disseminafion and Policy Committee will serve in an advisory capacity to the program project regarding the use of culturally appropriate approaches to build support from the community while maintaining scientific intergrity of the studies. The Administrative Core also will be responsible for determining that all studies involving samples from human subjects are approved bythe University of Minnesota Research Subjects Protection Programs Institutional Review Board Human Subjects Committee and the Masonic Cancer Center Protocol Review Committee, as well as the appropriate bodies at the University of Southern California and the University of Hawaii.
Lung cancer is the leading cause of cancer death in the world, killing 3500 people every day. The results of this program project grant research, if successful, will provide critical new insights for lung cancer prevention. The Administrative Core will ensure that this research runs smoothly and is well integrated both within the project and externally.
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|Degner, Amanda; Carlsson, Henrik; Karlsson, Isabella et al. (2018) Discovery of Novel N-(4-Hydroxybenzyl)valine Hemoglobin Adducts in Human Blood. Chem Res Toxicol :|
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|Murphy, Sharon E; Park, Sungshim Lani; Balbo, Silvia et al. (2018) Tobacco biomarkers and genetic/epigenetic analysis to investigate ethnic/racial differences in lung cancer risk among smokers. NPJ Precis Oncol 2:17|
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|Park, Sungshim L; Murphy, Sharon E; Wilkens, Lynne R et al. (2017) Association of CYP2A6 activity with lung cancer incidence in smokers: The multiethnic cohort study. PLoS One 12:e0178435|
|Murphy, Sharon E (2017) Nicotine Metabolism and Smoking: Ethnic Differences in the Role of P450 2A6. Chem Res Toxicol 30:410-419|
|Boldry, Emily J; Patel, Yesha M; Kotapati, Srikanth et al. (2017) Genetic Determinants of 1,3-Butadiene Metabolism and Detoxification in Three Populations of Smokers with Different Risks of Lung Cancer. Cancer Epidemiol Biomarkers Prev 26:1034-1042|
|Sangaraju, Dewakar; Boldry, Emily J; Patel, Yesha M et al. (2017) Isotope Dilution nanoLC/ESI+-HRMS3 Quantitation of Urinary N7-(1-Hydroxy-3-buten-2-yl) Guanine Adducts in Humans and Their Use as Biomarkers of Exposure to 1,3-Butadiene. Chem Res Toxicol 30:678-688|
|Peterson, Lisa A (2017) Context Matters: Contribution of Specific DNA Adducts to the Genotoxic Properties of the Tobacco-Specific Nitrosamine NNK. Chem Res Toxicol 30:420-433|
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