Core A (Administrative Core) will provide coordination and oversight of all activities of the Projects and Cores, and will maximize synergistic interactions among Project Leaders, Core Directors, and laboratory personnel. The administrative component will provide fiscal management, clerical and organizational support. Core A will provide guidance for conflict resolution and resource allocation. Fiscal management will include oversight of project and core budgets in accordance with policies and procedures of Columbia University and the NIH, as well as oversight of staff appointments, salaries and fringe benefits. To facilitate integration ofthe program and effective communication among its various members, Core A will organize monthly meetings of all Program participants for research presentations. Core A will also organize executive meetings, which will be limited to the Executive Committee (Drs. Gautier, Baer, Bhagat, Symington, and Zha). Finally, Core A will establish mechanisms for review of the Program Project by the Advisory Board. Core A will also facilitate interactions between individual projects and scientific cores B/C and the facilities in place at the Herbert Irving Comprehensive Cancer Center. Core A has the following specific aims: 1) Coordination of the overall program by supporting the organization ofthe program and implementing mechanisms for effective interaction among its personnel and by coordinating the interactions between projects, cores and existing facilities at the Cancer Center;2) Review of the Program Project by the Advisory Boards to evaluate ongoing progress of each Project, review the functionality of the Cores, and provide advice on future research directions. The administrative core services are therefore an integral and essential part ofthe Program to function as an integrated, efficient unit.

Public Health Relevance

The success of this Program Project Grant involves administrative and fiscal management, and coordination between projects and cores. This core will ensure that the pace of scientific discovery will move as quickly as possible so that the program goals are met in a timely fashion.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
1P01CA174653-01A1
Application #
8608849
Study Section
Special Emphasis Panel ()
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
1
Fiscal Year
2014
Total Cost
$77,750
Indirect Cost
$29,156
Name
Columbia University
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Yu, Tai-Yuan; Kimble, Michael T; Symington, Lorraine S (2018) Sae2 antagonizes Rad9 accumulation at DNA double-strand breaks to attenuate checkpoint signaling and facilitate end resection. Proc Natl Acad Sci U S A 115:E11961-E11969
Oh, Julyun; Lee, So Jung; Rothstein, Rodney et al. (2018) Xrs2 and Tel1 Independently Contribute to MR-Mediated DNA Tethering and Replisome Stability. Cell Rep 25:1681-1692.e4
Billing, David; Horiguchi, Michiko; Wu-Baer, Foon et al. (2018) The BRCT Domains of the BRCA1 and BARD1 Tumor Suppressors Differentially Regulate Homology-Directed Repair and Stalled Fork Protection. Mol Cell 72:127-139.e8
Schrank, Benjamin R; Aparicio, Tomas; Li, Yinyin et al. (2018) Nuclear ARP2/3 drives DNA break clustering for homology-directed repair. Nature 559:61-66
Gnügge, Robert; Oh, Julyun; Symington, Lorraine S (2018) Processing of DNA Double-Strand Breaks in Yeast. Methods Enzymol 600:1-24
Crowe, Jennifer L; Shao, Zhengping; Wang, Xiaobin S et al. (2018) Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination. Proc Natl Acad Sci U S A 115:8615-8620
Gnügge, Robert; Symington, Lorraine S (2017) Keeping it real: MRX-Sae2 clipping of natural substrates. Genes Dev 31:2311-2312
Liu, Xiangyu; Shao, Zhengping; Jiang, Wenxia et al. (2017) PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice. Nat Commun 8:13816
Kato, Niyo; Kawasoe, Yoshitaka; Williams, Hannah et al. (2017) Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway. Cell Rep 21:1375-1385
Yamamoto, Kenta; Wang, Jiguang; Sprinzen, Lisa et al. (2016) Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors. Elife 5:

Showing the most recent 10 out of 25 publications