The administrative core is designed to coordinate and support all of the activities of this Program. It will work proactively to assure complete synergy across the Research Projects and Cores around the theme of ?integrative genomics? that is the focus of the program. The Administrative Core will be led by Drs. Jim Gauderman, Duncan Thomas, and Graham Casey, collectively offering a broad range of administrative, multidisciplinary research, and translational experience needed to assure the success of the program. The Core will organize monthly meetings of the entire research team, coordinate scientific seminars, and hold an annual retreat. The Core has assembled an External Advisory Committee (EAC) comprising experts in statistical genetics, cancer genetic epidemiology, integrative genomics, bioinformatics, and high performance computing. The Core will coordinate one annual meeting of the EAC, and will facilitate additional interactions with the EAC via conference call, skype, etc. throughout the year as needed. The administrative core will coordinate travel, purchase supplies, monitor budgets, handle personnel issues, and submit annual progress reports for the program. Drs. Gauderman and Thomas will jointly assume responsibility for all organizational and financial activities of the project. In addition, Dr. Thomas will assume specific leadership of Project activities and Dr. Gauderman specific leadership of Core activities. These Project- and Core-specific roles will guarantee that both important elements of the overall program are being adequately administered. They will also establish the infrastructure needed for effective communications and collaboration across the Projects and Cores. Dr. Casey will provide overall scientific leadership related to the program focus on colorectal cancer. Specifically, he will assist in identifying the goals of statistical analysis and in the interpretation of corresponding results, both in the context of the current state of knowledge for this disease. Drs. Gaudeman, Thomas, and Casey will co-chair an Internal Executive Committee (IEC) consisting of each of the Project and Core directors. The IEC will meet quarterly to review progress and discuss issues, and Drs. Gauderman, Thomas, and Casey will solicit advice from the IEC as needed related to programmatic directions.

Public Health Relevance

The administrative core will provide scientific oversight, enhance communications among investigators, and support all of the activities of this program. It will work proactively to assure complete synergy across the Research Projects and Cores around the theme of ?integrative genomics? that is the focus of the program.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
1P01CA196569-01A1
Application #
9072853
Study Section
Special Emphasis Panel (ZCA1)
Project Start
2016-07-01
Project End
2021-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
1
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of Southern California
Department
Type
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90032
Ryser, Marc D; Min, Byung-Hoon; Siegmund, Kimberly D et al. (2018) Spatial mutation patterns as markers of early colorectal tumor cell mobility. Proc Natl Acad Sci U S A 115:5774-5779
Liu, Jie; Liang, Gangning; Siegmund, Kimberly D et al. (2018) Data integration by multi-tuning parameter elastic net regression. BMC Bioinformatics 19:369
Moss, Lilit C; Gauderman, William J; Lewinger, Juan Pablo et al. (2018) Using Bayes model averaging to leverage both gene main effects and G?×? E interactions to identify genomic regions in genome-wide association studies. Genet Epidemiol :
Chopra, Sameer; Liu, Jie; Alemozaffar, Mehrdad et al. (2017) Improving needle biopsy accuracy in small renal mass using tumor-specific DNA methylation markers. Oncotarget 8:5439-5448
Croteau-Chonka, Damien C; Qiu, Weiliang; Martinez, Fernando D et al. (2017) Gene Expression Profiling in Blood Provides Reproducible Molecular Insights into Asthma Control. Am J Respir Crit Care Med 195:179-188
McAllister, Kimberly; Mechanic, Leah E; Amos, Christopher et al. (2017) Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases. Am J Epidemiol 186:753-761
Raskin, Leon; Guo, Yan; Du, Liping et al. (2017) Targeted sequencing of established and candidate colorectal cancer genes in the Colon Cancer Family Registry Cohort. Oncotarget 8:93450-93463
Ritchie, Marylyn D; Davis, Joe R; Aschard, Hugues et al. (2017) Incorporation of Biological Knowledge Into the Study of Gene-Environment Interactions. Am J Epidemiol 186:771-777
Patel, Chirag J; Kerr, Jacqueline; Thomas, Duncan C et al. (2017) Opportunities and Challenges for Environmental Exposure Assessment in Population-Based Studies. Cancer Epidemiol Biomarkers Prev 26:1370-1380
Thomas, Paul D (2017) The Gene Ontology and the Meaning of Biological Function. Methods Mol Biol 1446:15-24

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