Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Program Projects (P01)
Project #
5P01DA008924-13
Application #
7513122
Study Section
Special Emphasis Panel (ZDA1-KXA-N (03))
Project Start
2007-09-01
Project End
2008-08-31
Budget Start
2007-09-01
Budget End
2008-08-31
Support Year
13
Fiscal Year
2007
Total Cost
$187,852
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Type
DUNS #
060217502
City
New York
State
NY
Country
United States
Zip Code
10065
Szeto, H H; Birk, A V (2014) Serendipity and the discovery of novel compounds that restore mitochondrial plasticity. Clin Pharmacol Ther 96:672-83
Shimoyama, Megumi; Schiller, Peter W; Shimoyama, Naohito et al. (2012) Superior analgesic effect of H-Dmt-D-Arg-Phe-Lys-NH2 ([Dmt1]DALDA), a multifunctional opioid peptide, compared to morphine in a rat model of neuropathic pain. Chem Biol Drug Des 80:771-4
Han, Zhaosheng; Varadharaj, Saradhadevi; Giedt, Randy J et al. (2009) Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells. J Pharmacol Exp Ther 329:94-101
Yang, Lichuan; Zhao, Kesheng; Calingasan, Noel Y et al. (2009) Mitochondria targeted peptides protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. Antioxid Redox Signal 11:2095-104
Shimoyama, Megumi; Szeto, Hazel H; Schiller, Peter W et al. (2009) Differential analgesic effects of a mu-opioid peptide, [Dmt(1)]DALDA, and morphine. Pharmacology 83:33-7
Fichna, Jakub; do-Rego, Jean-Claude; Chung, Nga N et al. (2008) [Dmt1, d-1-Nal3]morphiceptin, a novel opioid peptide analog with high analgesic activity. Peptides 29:633-8
Szeto, Hazel H (2008) Development of mitochondria-targeted aromatic-cationic peptides for neurodegenerative diseases. Ann N Y Acad Sci 1147:112-21
Fichna, Jakub; do-Rego, Jean-Claude; Janecki, Tomasz et al. (2008) Novel highly potent mu-opioid receptor antagonist based on endomorphin-2 structure. Bioorg Med Chem Lett 18:1350-3
Mizuguchi, Yasunori; Chen, Jie; Seshan, Surya V et al. (2008) A novel cell-permeable antioxidant peptide decreases renal tubular apoptosis and damage in unilateral ureteral obstruction. Am J Physiol Renal Physiol 295:F1545-53
Szeto, Hazel H (2008) Mitochondria-targeted cytoprotective peptides for ischemia-reperfusion injury. Antioxid Redox Signal 10:601-19

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