iThe aims of the administrative core are to set and implement programmafic goals and operafing procedures ,or the overall research as well as facilitate communicafion between projects and cores. Moreover, the core will monitor and develop scientific exchanges among all invesfigators and the Internal and External Advisory Committees. This will provide monitoring for scientific progress;maintain a system for fiscal accountability;oversee confiict of interests;provide broad statisfical support, and assist in the planning, implementafion of experiments and interpretafion of data for publications, patent applicafions, and ulfimately a pathway towards clinical product development. Most importanfiy the core will serve to integrate research activifies ongoing between each of the projects and the scientific cores. Dr. H. Gendelman will serve to organize and implement all acfivifies and will be assisted by a program coordinator, Dr. R. L. Mosley and a scientific codirector. Dr. H. Fox. The biostatisfical core will be led by Dr. Jane Meza;an experienced biostafistical expert.

Public Health Relevance

Antiretroviral therapies are the mainstay for HIV/AIDS treatments. Drug access, adherence, compliance and untoward toxicifies remain commonplace and most notably for substance abusers. We posit that specific drug targefing to sites of acfive viral growth in a safe, extended-release injectable formula will improve disease outcomes and have profound posifive clinical outcomes for substance abusers.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Program Projects (P01)
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Special Emphasis Panel (ZRG1-AARR-D (40))
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University of Nebraska Medical Center
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McMillan, JoEllyn M; Cobb, Denise A; Lin, Zhiyi et al. (2018) Antiretroviral Drug Metabolism in Humanized PXR-CAR-CYP3A-NOG Mice. J Pharmacol Exp Ther 365:272-280
McMillan, JoEllyn; Szlachetka, Adam; Zhou, Tian et al. (2018) Pharmacokinetic testing of a first generation cabotegravir prodrug in rhesus macaques. AIDS :
Montenegro-Burke, J Rafael; Woldstad, Christopher J; Fang, Mingliang et al. (2018) Nanoformulated Antiretroviral Therapy Attenuates Brain Metabolic Oxidative Stress. Mol Neurobiol :
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Schutt, Charles R; Gendelman, Howard E; Mosley, R Lee (2018) Tolerogenic bone marrow-derived dendritic cells induce neuroprotective regulatory T cells in a model of Parkinson's disease. Mol Neurodegener 13:26
Sillman, Brady; Bade, Aditya N; Dash, Prasanta K et al. (2018) Creation of a long-acting nanoformulated dolutegravir. Nat Commun 9:443
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Thomas, Midhun B; Gnanadhas, Divya Prakash; Dash, Prasanta K et al. (2018) Modulating cellular autophagy for controlled antiretroviral drug release. Nanomedicine (Lond) 13:2139-2154
Kiyota, Tomomi; Machhi, Jatin; Lu, Yaman et al. (2018) URMC-099 facilitates amyloid-? clearance in a murine model of Alzheimer's disease. J Neuroinflammation 15:137
Guijas, Carlos; Montenegro-Burke, J Rafael; Warth, Benedikt et al. (2018) Metabolomics activity screening for identifying metabolites that modulate phenotype. Nat Biotechnol 36:316-320

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