The Morphology Core of Kresge Hearing Research Institute provides morphological processing and assessments for the entire Program Project. The Core will handle the processing and analysis of tissues with a variety of morphological methods. The major part of the work will be performed by two full time research assistants, Peter A. Finger and Annapurna Ramakrishnan. Planning and supervision of the work, quality control and assessments of the results will be performed by Dr. Raphael. Drs. Altschuler and Hawkins will be available as consultants. Dr. Raphael and Dr. Middlebrooks will share the responsibility for coordinating the distribution of the load of work between the Core and the PIs on the sub- projects. All methods proposed for use by the Core are already in routine use in our laboratory. Publication for previous years include extensive use of the majority of these methods. Close working relationship exist between the PIs on the different projects and between the PI on the Core and the technical assistants. To further promote efficient and successful Core operation, frequent meetings will be set between the Core PI and the other PIs, to discuss progress and plan next steps in each of the specific aims. Dr. Raphael will also be involved in preparing the data for presentation in meetings or peer reviewed papers.

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University of Michigan Ann Arbor
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Stefanescu, Roxana A; Koehler, Seth D; Shore, Susan E (2015) Stimulus-timing-dependent modifications of rate-level functions in animals with and without tinnitus. J Neurophysiol 113:956-70
Basura, Gregory J; Koehler, Seth D; Shore, Susan E (2015) Bimodal stimulus timing-dependent plasticity in primary auditory cortex is altered after noise exposure with and without tinnitus. J Neurophysiol 114:3064-75
Le Prell, Colleen G; Hughes, Larry F; Bledsoe Jr, Sanford C (2014) Dynorphin release by the lateral olivocochlear efferents may inhibit auditory nerve activity: a cochlear drug delivery study. Neurosci Lett 571:17-22
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Koehler, Seth D; Shore, Susan E (2013) Stimulus-timing dependent multisensory plasticity in the guinea pig dorsal cochlear nucleus. PLoS One 8:e59828
Basura, Gregory J; Koehler, Seth D; Shore, Susan E (2012) Multi-sensory integration in brainstem and auditory cortex. Brain Res 1485:95-107
Dehmel, Susanne; Pradhan, Shashwati; Koehler, Seth et al. (2012) Noise overexposure alters long-term somatosensory-auditory processing in the dorsal cochlear nucleus--possible basis for tinnitus-related hyperactivity? J Neurosci 32:1660-71
Koehler, Seth D; Pradhan, Shashwati; Manis, Paul B et al. (2011) Somatosensory inputs modify auditory spike timing in dorsal cochlear nucleus principal cells. Eur J Neurosci 33:409-20
Bledsoe Jr, Sanford C; Koehler, Seth; Tucci, Debara L et al. (2009) Ventral cochlear nucleus responses to contralateral sound are mediated by commissural and olivocochlear pathways. J Neurophysiol 102:886-900
Skjonsberg, Asa; Halsey, Karin; Ulfendahl, Mats et al. (2007) Exploring efferent-mediated DPOAE adaptation in three different guinea pig strains. Hear Res 224:27-33

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