Abstract

A central theme in this PPG is the genetically engineered mouse. This Core is the Gene-Targeted Mouse Facility, located at The Rockefeller University. The facility will provide the gene=targeted mice that will be used in each of the subprojects. Most of these mice have already been developed by Dr. Mombaerts in his laboratory at The Rockefeller University. New strains will be developed and deposited in this core. Because duplicating these lines of mice at other institutions is costly and because quality control must be stringent, we have elected to utilize a single facility through which mice will be distribute to each of the groups. Centralized breeding of the gene-targeted mice will not pose a hurdle because of the geographical proximity of the various laboratories.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Program Projects (P01)
Project #
5P01DC003887-04
Application #
6655181
Study Section
Communication Disorders Review Committee (CDRC)
Project Start
2002-07-01
Project End
2003-06-30
Budget Start
Budget End
Support Year
4
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Yale University
Department
Type
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Treloar, Helen B; Uboha, Ulyana; Jeromin, Andreas et al. (2005) Expression of the neuronal calcium sensor protein NCS-1 in the developing mouse olfactory pathway. J Comp Neurol 482:201-16
Ma, Minghong; Grosmaitre, Xavier; Iwema, Carrie L et al. (2003) Olfactory signal transduction in the mouse septal organ. J Neurosci 23:317-24
Treloar, Helen B; Gabeau, Darlene; Yoshihara, Yoshihiro et al. (2003) Inverse expression of olfactory cell adhesion molecule in a subset of olfactory axons and a subset of mitral/tufted cells in the developing rat main olfactory bulb. J Comp Neurol 458:389-403
Lipscomb, Brian W; Treloar, Helen B; Klenoff, Jason et al. (2003) Cell surface carbohydrates and glomerular targeting of olfactory sensory neuron axons in the mouse. J Comp Neurol 467:22-31
Treloar, Helen B; Feinstein, Paul; Mombaerts, Peter et al. (2002) Specificity of glomerular targeting by olfactory sensory axons. J Neurosci 22:2469-77
Lipscomb, Brian W; Treloar, Helen B; Greer, Charles A (2002) Cell surface carbohydrates reveal heterogeneity in olfactory receptor cell axons in the mouse. Cell Tissue Res 308:7-17
Lipscomb, Brian W; Treloar, Helen B; Greer, Charles A (2002) Novel microglomerular structures in the olfactory bulb of mice. J Neurosci 22:766-74
Zou, Dong-Jing; Greer, Charles A; Firestein, Stuart (2002) Expression pattern of alpha CaMKII in the mouse main olfactory bulb. J Comp Neurol 443:226-36
Au, Winnie W; Treloar, Helen B; Greer, Charles A (2002) Sublaminar organization of the mouse olfactory bulb nerve layer. J Comp Neurol 446:68-80
Kim, H; Greer, C A (2000) The emergence of compartmental organization in olfactory bulb glomeruli during postnatal development. J Comp Neurol 422:297-311

Showing the most recent 10 out of 12 publications