This core includes the data management, analysis and administrative support for the grant and describes the patient population utilized in all patient- based sections of the program. The families with autosomal dominant polycystic kidney disease (ADPKD) who have been collected for more than 30 years at the University of Colorado are a unique resource for the longitudinal study of human ADPKD. This population includes, but is not restricted to, the 1021 members of 314 ADPKD families who were seen in the last two granting periods. These subjects were classified on the basis of abdominal ultrasonography or gene linkage analysis as wither definite ADPKD (N=621), suspicious for the disease (N=23) or negative (N=377). This population includes ADPKD1 and ADPKD2 families, including the largest and most completely studied ADPKD2 family. The historical, physical examination, laboratory and imaging data of all these subjects are entered into the ADPKD database and have been extensively analyzed. The data management section is engaged in data entry, data verification and data analysis support for the entire program. The administrative support for the program is responsible for coordination of the flow of patients into specific studies, handling all the scheduling, patients travel, patient and physician correspondence and inquiries, overseeing all budgetary aspects of the grant, and organizing the Advisory Board meetings. All investigators will meet with the Advisory Board at the end of years 12 and 14.

Project Start
2001-04-21
Project End
2001-07-31
Budget Start
Budget End
Support Year
15
Fiscal Year
2001
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Type
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
Perrone, Ronald D; Mouksassi, Mohamad-Samer; Romero, Klaus et al. (2017) Total Kidney Volume Is a Prognostic Biomarker of Renal Function Decline and Progression to End-Stage Renal Disease in Patients With Autosomal Dominant Polycystic Kidney Disease. Kidney Int Rep 2:442-450
Perrone, Ronald D; Mouksassi, Mohamad-Samer; Romero, Klaus et al. (2017) A Drug Development Tool for Trial Enrichment in Patients With Autosomal Dominant Polycystic Kidney Disease. Kidney Int Rep 2:451-460
Nowak, Kristen L; Cadnapaphornchai, Melissa A; Chonchol, Michel B et al. (2016) Long-Term Outcomes in Patients with Very-Early Onset Autosomal Dominant Polycystic Kidney Disease. Am J Nephrol 44:171-8
Schrier, Robert W; Abebe, Kaleab Z; Perrone, Ronald D et al. (2014) Blood pressure in early autosomal dominant polycystic kidney disease. N Engl J Med 371:2255-66
Helal, Imed; Reed, Berenice; Mettler, Pamela et al. (2012) Prevalence of cardiovascular events in patients with autosomal dominant polycystic kidney disease. Am J Nephrol 36:362-70
Reed, Berenice Y; Masoumi, Amirali; Elhassan, Elwaleed et al. (2011) Angiogenic growth factors correlate with disease severity in young patients with autosomal dominant polycystic kidney disease. Kidney Int 79:128-34
Helal, Imed; Reed, Berenice; McFann, Kim et al. (2011) Glomerular hyperfiltration and renal progression in children with autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol 6:2439-43
Reed, Berenice; McFann, Kim; Kimberling, William J et al. (2008) Presence of de novo mutations in autosomal dominant polycystic kidney disease patients without family history. Am J Kidney Dis 52:1042-50
Reed, Berenice Y; McFann, Kim; Bekheirnia, Mir R et al. (2008) Variation in age at ESRD in autosomal dominant polycystic kidney disease. Am J Kidney Dis 51:173-83
Tao, Yunxia; Zafar, Iram; Kim, Jun et al. (2008) Caspase-3 gene deletion prolongs survival in polycystic kidney disease. J Am Soc Nephrol 19:749-55

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