The Administrative Core, directed by Dr. Susan Taylor with Dr. Alexandra Newton serving as Assistant Director, will perform all of the administrative functions require by the program. To achieve this we have established a Project Manager, Grace Liu, who will work closely with Drs. Taylor and Newton, with each PI, and with each of the core leaders. This will include accounting, organization of scientific interactions, organization and coordination of monthly meetings, organization and coordination of invited speakers to the UCSD campus, organization and coordination of workshops in San Diego, and preparation of manuscripts and progress reports. She will also manage the budgets and track ordering and spending. All of the investigators are on the UCSD campus except for Dr. John Scott who has recently moved from the Vollum Institute in Portland, Oregon, to the Department of Pharmacology at the University of Washington where he holds the Edwin G. Krebs Chair. A major goal for this next granting period will be to organize biennial meetings that are held alternatively in San Diego and Seattle. There is historically a strong link between the two campuses in the area of signal transduction, and we would like to re-establish this axis. Planning an implementation of these meetings would also come under the purview of the Administrative Core. We also will have access to the San Diego Supercomputer Center and to Cal-IT2, which provide important key resources for our cores and for our bioinformatics specialist who will be funded in part from matching funds from the university. This individual will interface closely with Cores A. B. and C and will link many of the structural, biochemical, mass spectrometry and imaging components of the program. These are all data intensive endeavors. In addition, he/she will interface with other computational resources at UCSD such as the Protein Data Bank, the National Center for Microscopy and Imaging Research (NICMIR) headed by Dr. Mark Ellisman who also is the director of Core B, and the Phenotyping Core facility that is funded by NIDDK.

Public Health Relevance

Given the diversity of our team and the interdisciplinary nature of the research that we are doing it is essential to have a central coordinator for our PPG. Planning of workshops and coordination between research teams requires strong central leadership that goes beyond any one project or core. The smooth integration of all the projects and cores is a major cornerstone for our success.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Diego
La Jolla
United States
Zip Code
Flippo, Kyle H; Gnanasekaran, Aswini; Perkins, Guy A et al. (2018) AKAP1 Protects from Cerebral Ischemic Stroke by Inhibiting Drp1-Dependent Mitochondrial Fission. J Neurosci 38:8233-8242
Sengupta, Soham; Nechushtai, Rachel; Jennings, Patricia A et al. (2018) Phylogenetic analysis of the CDGSH iron-sulfur binding domain reveals its ancient origin. Sci Rep 8:4840
Haushalter, Kristofer J; Casteel, Darren E; Raffeiner, Andrea et al. (2018) Phosphorylation of protein kinase A (PKA) regulatory subunit RI? by protein kinase G (PKG) primes PKA for catalytic activity in cells. J Biol Chem 293:4411-4421
Sastri, Mira; Darshi, Manjula; Mackey, Mason et al. (2017) Sub-mitochondrial localization of the genetic-tagged mitochondrial intermembrane space-bridging components Mic19, Mic60 and Sam50. J Cell Sci 130:3248-3260
Smith, F Donelson; Esseltine, Jessica L; Nygren, Patrick J et al. (2017) Local protein kinase A action proceeds through intact holoenzymes. Science 356:1288-1293
Parker, Seth J; Svensson, Robert U; Divakaruni, Ajit S et al. (2017) LKB1 promotes metabolic flexibility in response to energy stress. Metab Eng 43:208-217
Nystoriak, Matthew A; Nieves-CintrĂ³n, Madeline; Patriarchi, Tommaso et al. (2017) Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes. Sci Signal 10:
Ilouz, Ronit; Lev-Ram, Varda; Bushong, Eric A et al. (2017) Isoform-specific subcellular localization and function of protein kinase A identified by mosaic imaging of mouse brain. Elife 6:
Nygren, Patrick J; Mehta, Sohum; Schweppe, Devin K et al. (2017) Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity. Elife 6:
Aggarwal-Howarth, Stacey; Scott, John D (2017) Pseudoscaffolds and anchoring proteins: the difference is in the details. Biochem Soc Trans 45:371-379

Showing the most recent 10 out of 216 publications