Abstract

Studies are proposed in this application to study N0S isoform expression in keratinocytes and the mechanisms by which G proteins control N0 production in the skin. The primary hypothesis to be tested is that G proteins participate in the regulation of N0 biosynthesis in keratinocytes following cytokine challenge or toxic injury.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES006897-05
Application #
6486001
Study Section
Project Start
2001-09-01
Project End
2003-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
5
Fiscal Year
2001
Total Cost
$134,676
Indirect Cost

  Institution

Name
University of Medicine & Dentistry of NJ
Department
Type
DUNS #
622146454
City
Piscataway
State
NJ
Country
United States
Zip Code
08854

  Publications

Jan, Yi-Hua; Richardson, Jason R; Baker, Angela A et al. (2016) Novel approaches to mitigating parathion toxicity: targeting cytochrome P450-mediated metabolism with menadione. Ann N Y Acad Sci 1378:80-86
Kazanecki, Christian C; Kowalski, Aaron J; Ding, Tony et al. (2007) Characterization of anti-osteopontin monoclonal antibodies: Binding sensitivity to post-translational modifications. J Cell Biochem 102:925-35
Kazanecki, Christian C; Uzwiak, Dana J; Denhardt, David T (2007) Control of osteopontin signaling and function by post-translational phosphorylation and protein folding. J Cell Biochem 102:912-24
Gray, Joshua P; Heck, Diane E; Mishin, Vladimir et al. (2007) Paraquat increases cyanide-insensitive respiration in murine lung epithelial cells by activating an NAD(P)H:paraquat oxidoreductase: identification of the enzyme as thioredoxin reductase. J Biol Chem 282:7939-49
Ishijima, Muneaki; Ezura, Yoichi; Tsuji, Kunikazu et al. (2006) Osteopontin is associated with nuclear factor kappaB gene expression during tail-suspension-induced bone loss. Exp Cell Res 312:3075-83
Vetrano, Anna M; Heck, Diane E; Mariano, Thomas M et al. (2005) Characterization of the oxidase activity in mammalian catalase. J Biol Chem 280:35372-81
Martey, Christine A; Vetrano, Anna M; Whittemore, Marilyn S et al. (2005) Inhibition of interferon-gamma signaling by a mercurio-substituted dihydropsoralen in murine keratinocytes. Biochem Pharmacol 70:1726-34
Heck, Diane E; Kagan, Valerian E; Shvedova, Anna A et al. (2005) An epigrammatic (abridged) recounting of the myriad tales of astonishing deeds and dire consequences pertaining to nitric oxide and reactive oxygen species in mitochondria with an ancillary missive concerning the origins of apoptosis. Toxicology 208:259-71
Fakhrzadeh, Ladan; Laskin, Jeffrey D; Gardner, Carol R et al. (2004) Superoxide dismutase-overexpressing mice are resistant to ozone-induced tissue injury and increases in nitric oxide and tumor necrosis factor-alpha. Am J Respir Cell Mol Biol 30:280-7
Heck, Diane E; Gerecke, Donald R; Vetrano, Anna M et al. (2004) Solar ultraviolet radiation as a trigger of cell signal transduction. Toxicol Appl Pharmacol 195:288-97

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