The Research Development Core will provide seed money for pilot projects to attract new investigators to the itudy of Gene-Environment interactions in PD, foster collaborations between investigators from different disciplines, such as epidemiology, neurology, toxicology, genetic, and basic neuroscience, and provide the possibility to test innovative ideas and gather preliminary data for larger scale studies supported by new grants. Applications will be solicited-in person and through broad-mailing to UCLA investigators that may contribute novel expertise to the study of PD. Proposals will be reviewed anonymously and funding decisions made by the Steering Committee of the Center. Applicants and recipients of pilot funds will be invited to all activities of the Center (monthly meetings, annual symposium, External Advisory Board visits) and be required to present their project and progress on these occasions. Long term assessment of the success of the research core will include yearly updates on progress, publications, collaborations and grant support.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES016732-03
Application #
8117808
Study Section
Special Emphasis Panel (ZES1)
Project Start
Project End
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
3
Fiscal Year
2010
Total Cost
$118,385
Indirect Cost
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Kusters, Cynthia D J; Paul, Kimberly C; Guella, Ilaria et al. (2018) Dopamine receptors and BDNF-haplotypes predict dyskinesia in Parkinson's disease. Parkinsonism Relat Disord 47:39-44
Paul, Kimberly C; Sinsheimer, Janet S; Cockburn, Myles et al. (2018) NFE2L2, PPARGC1?, and pesticides and Parkinson's disease risk and progression. Mech Ageing Dev 173:1-8
Chen, Honglei; Ritz, Beate (2018) The Search for Environmental Causes of Parkinson's Disease: Moving Forward. J Parkinsons Dis 8:S9-S17
Richter, Franziska; Subramaniam, Sudhakar R; Magen, Iddo et al. (2017) A Molecular Tweezer Ameliorates Motor Deficits in Mice Overexpressing ?-Synuclein. Neurotherapeutics 14:1107-1119
Sanders, Laurie H; Paul, Kimberly C; Howlett, Evan H et al. (2017) Editor's Highlight: Base Excision Repair Variants and Pesticide Exposure Increase Parkinson's Disease Risk. Toxicol Sci 158:188-198
Aguilar, Jenny I; Dunn, Matthew; Mingote, Susana et al. (2017) Neuronal Depolarization Drives Increased Dopamine Synaptic Vesicle Loading via VGLUT. Neuron 95:1074-1088.e7
Paul, Kimberly C; Sinsheimer, Janet S; Cockburn, Myles et al. (2017) Organophosphate pesticides and PON1 L55M in Parkinson's disease progression. Environ Int 107:75-81
Chuang, Yu-Hsuan; Paul, Kimberly C; Bronstein, Jeff M et al. (2017) Parkinson's disease is associated with DNA methylation levels in human blood and saliva. Genome Med 9:76
Richter, Franziska; Gabby, Lauryn; McDowell, Kimberly A et al. (2017) Effects of decreased dopamine transporter levels on nigrostriatal neurons and paraquat/maneb toxicity in mice. Neurobiol Aging 51:54-66
Narayan, Shilpa; Liew, Zeyan; Bronstein, Jeff M et al. (2017) Occupational pesticide use and Parkinson's disease in the Parkinson Environment Gene (PEG) study. Environ Int 107:266-273

Showing the most recent 10 out of 78 publications