The primary goals of this Children's Center are to use a multidisciplinary approach to address critical gaps in our knowledge about the impact of exposure to endocrine disrupting chemicals (phthalates/BPA) on child development, to actively involve junior investigators in this research effort, and to actively communicate our research findings to parents, childcare providers and healthcare providers. There are three common themes that unite the three research projects and the Outreach and Translation Core (COTC) of this Center: (1) assessment of exposures during two critical developmental windows (prenatal and adolescent), (2) investigation of joint effects of phthalate/BPA exposure and a high fat diet/obesity, and (3) investigation of the role of oxidative stress and inflammation in mediating effects. At the heart of the research effort will be two human cohorts (Project 1)-a prospective pre-birth cohort currently in progress in Urbana, Illinois and an adolescent cohort to be assessed as part of a long-standing prospective study in New Bedford, Massachusetts. The Center will also include laboratory animal projects (Projects 2 and 3) which will model the timing of exposures in these human cohorts, a COTC, and this administrative core which will provide oversight, coordination and integration of all Center-related activities. The responsibilities of the Administrative Core will include organizing and scheduling monthly meetings of the Internal Advisory Committee and monthly research team meetings of the Center investigators, organizing yearly meetings of the Center scientists with the six-member External Advisory Committee, coordinating the career development activities of the Center, and facilitating interactions of the Pediatric Health Specialist with the COTC to communicate research findings to the healthcare community. As Director and Associate Director of the Children's Center, Drs. Susan Schantz and Jodi Flaws will be responsible for conducting Internal and External Advisory Committee meetings and regularly evaluating the research progress of each of the projects, as well as the outreach activities of the COTC. They will also be responsible for general fiscal oversight of the Center. Dr. Flaws will have full authority to make decisions in Dr. Schantz's absence. Relevance: Phthalates and BPA are endocrine disrupting chemicals that are found in many consumer products. Exposure is widespread, but the impact of this exposure on child health and development is not well-understood. This Center's research will fill an important gap in our knowledge by investigating the effects of these chemicals, both alone and combination with a high fat diet on reproductive and neural development.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
3P01ES022848-05S1
Application #
9751464
Study Section
Special Emphasis Panel (ZES1)
Program Officer
Gray, Kimberly A
Project Start
2013-06-15
Project End
2019-05-31
Budget Start
2018-07-01
Budget End
2019-05-31
Support Year
5
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Illinois Urbana-Champaign
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
Yazdy, Mahsa M; Coull, Brent A; Gardiner, Joseph C et al. (2018) A possible approach to improving the reproducibility of urinary concentrations of phthalate metabolites and phenols during pregnancy. J Expo Sci Environ Epidemiol 28:448-460
Stavans, Maayan; Baillargeon, Renée (2018) Four-month-old infants individuate and track simple tools following functional demonstrations. Dev Sci 21:
Brehm, Emily; Rattan, Saniya; Gao, Liying et al. (2018) Prenatal Exposure to Di(2-Ethylhexyl) Phthalate Causes Long-Term Transgenerational Effects on Female Reproduction in Mice. Endocrinology 159:795-809
Strakovsky, Rita S; Schantz, Susan L (2018) Impacts of bisphenol A (BPA) and phthalate exposures on epigenetic outcomes in the human placenta. Environ Epigenet 4:dvy022
Li, Quanxi; Lawrence, Catherine R; Nowak, Romana A et al. (2018) Bisphenol A and Phthalates Modulate Peritoneal Macrophage Function in Female Mice Involving SYMD2-H3K36 Dimethylation. Endocrinology 159:2216-2228
Mahalingam, Sharada; Ther, Laura; Gao, Liying et al. (2017) The effects of in utero bisphenol A exposure on ovarian follicle numbers and steroidogenesis in the F1 and F2 generations of mice. Reprod Toxicol 74:150-157
Barakat, Radwa; Lin, Po-Ching Patrick; Rattan, Saniya et al. (2017) Prenatal Exposure to DEHP Induces Premature Reproductive Senescence in Male Mice. Toxicol Sci 156:96-108
Zhou, Changqing; Gao, Liying; Flaws, Jodi A (2017) Prenatal exposure to an environmentally relevant phthalate mixture disrupts reproduction in F1 female mice. Toxicol Appl Pharmacol 318:49-57
Zhou, Changqing; Gao, Liying; Flaws, Jodi A (2017) Exposure to an Environmentally Relevant Phthalate Mixture Causes Transgenerational Effects on Female Reproduction in Mice. Endocrinology 158:1739-1754
Park, Chan Jin; Chen, Guanglin; Koo, Yongbum et al. (2017) Generation and characterization of an estrogen receptor alpha-iCre knock-in mouse. Genesis 55:

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