""""""""Project D: Core Resources"""""""" represents the physical and administrative core of the Program Project. Major expenses related to general infrastructure support are included In this section in order to centralize the support activities on which all of the other projects rely. The major items that represent the bulk of the budget for this section include the service contracts on the electron microscopes, systems management and maintenance of computers, upkeep and development of miscellaneous equipment, and our share of the maintenance of equipment that is shared with other investigators in Donner Lab who are not participants in the Program Project. General research on improvement of the efficiency and quality of data collection is carried out in the context of the CORE. Certain expenses that might be considered part of the basic administrative infrastructure, and which are nevertheless charged as direct costs (such as telephone service, space and electricity), are budgeted in the Core Resources. The Core Resources budget also includes costs for the fraction of personnel effort associated the infrastructure maintenance and with the scientific management of the Core facilities as well as the Program Project as a whole.

Public Health Relevance

Structural studies enabled by the core contribute to our understanding of cell biology at the molecular level that will help understand the causes and potential treatments for several diseases and other medical problems. Electron microscopy research on microtubule- and actin-based systems will lead to better understanding of a number of functional mechanisms within the cell.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Research Program Projects (P01)
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Special Emphasis Panel (ZRG1-CB-B (40))
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Lawrence Berkeley National Laboratory
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Zhang, Rui; LaFrance, Benjamin; Nogales, Eva (2018) Separating the effects of nucleotide and EB binding on microtubule structure. Proc Natl Acad Sci U S A 115:E6191-E6200
Nogales, Eva (2018) Cytoskeleton in high resolution. Nat Rev Mol Cell Biol 19:142
Downing, Kenneth H; Glaeser, Robert M (2018) Estimating the effect of finite depth of field in single-particle cryo-EM. Ultramicroscopy 184:94-99
Nogales, Eva (2018) Cryo-EM. Curr Biol 28:R1127-R1128
Sazzed, Salim; Song, Junha; Kovacs, Julio A et al. (2018) Tracing Actin Filament Bundles in Three-Dimensional Electron Tomography Density Maps of Hair Cell Stereocilia. Molecules 23:
Kamennaya, Nina A; Zemla, Marcin; Mahoney, Laura et al. (2018) High pCO2-induced exopolysaccharide-rich ballasted aggregates of planktonic cyanobacteria could explain Paleoproterozoic carbon burial. Nat Commun 9:2116
Howes, Stuart C; Geyer, Elisabeth A; LaFrance, Benjamin et al. (2018) Structural and functional differences between porcine brain and budding yeast microtubules. Cell Cycle 17:278-287
Glaeser, Robert M (2018) PROTEINS, INTERFACES, AND CRYO-EM GRIDS. Curr Opin Colloid Interface Sci 34:1-8
Kellogg, Elizabeth H; Hejab, Nisreen M A; Poepsel, Simon et al. (2018) Near-atomic model of microtubule-tau interactions. Science 360:1242-1246
Chiu, Wah; Downing, Kenneth H (2017) Editorial overview: Cryo Electron Microscopy: Exciting advances in CryoEM Herald a new era in structural biology. Curr Opin Struct Biol 46:iv-viii

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