Abstract

The specific objectives of the Neurohistology, Morphometry, and Data Processing Core are to provide neuroanatomic, neuropathologic, and morpnometric analysis for all appropriate postnatal brains generated by each of the Research Components of the Program Project. As the 'central warehouse' of all postnatal neuroanatomic material, this Core is a natural repository for all behavioral, anatomic, and morphometric data from each of the Projects, as well as an ideal resource for statistical support for the Program Project as a whole. The Core will be involved in the steps leading to publication of all results that contain neuroanatomic and pathologic findings, and for this purpose it will provide support to the several research Projects in the preparation of illustrations of postnatal neuroanatomic and pathologic materials. Some of the additional activities of this Core, but which are not part of the current application, include the processing of human brains of individuals with learning disorders and control specimens, which are used to describe neuroanatomic findings and generate neuroanatomic hypotheses that can be tested in animal models such as those in the present Program Project.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD057853-04
Application #
8376375
Study Section
Special Emphasis Panel (ZHD1-MRG-C)
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
4
Fiscal Year
2012
Total Cost
$169,423
Indirect Cost
$40,582

  Institution

Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Rendall, Amanda R; Ford, Aiden L; Perrino, Peter A et al. (2017) Auditory processing enhancements in the TS2-neo mouse model of Timothy Syndrome, a rare genetic disorder associated with autism spectrum disorders. Adv Neurodev Disord 1:176-189
Rendall, Amanda R; Tarkar, Aarti; Contreras-Mora, Hector M et al. (2017) Deficits in learning and memory in mice with a mutation of the candidate dyslexia susceptibility gene Dyx1c1. Brain Lang 172:30-38
Che, Alicia; Truong, Dongnhu T; Fitch, R Holly et al. (2016) Mutation of the Dyslexia-Associated Gene Dcdc2 Enhances Glutamatergic Synaptic Transmission Between Layer 4 Neurons in Mouse Neocortex. Cereb Cortex 26:3705-3718
Chen, Fuyi; Becker, Albert; LoTurco, Joseph (2016) Overview of Transgenic Glioblastoma and Oligoastrocytoma CNS Models and Their Utility in Drug Discovery. Curr Protoc Pharmacol 72:14.37.1-12
Rendall, Amanda R; Truong, Dongnhu T; Fitch, R Holly (2016) Learning delays in a mouse model of Autism Spectrum Disorder. Behav Brain Res 303:201-7
Truong, Dongnhu T; Rendall, Amanda R; Rosen, Glenn D et al. (2015) Morphometric changes in subcortical structures of the central auditory pathway in mice with bilateral nodular heterotopia. Behav Brain Res 282:61-9
Truong, D T; Che, A; Rendall, A R et al. (2014) Mutation of Dcdc2 in mice leads to impairments in auditory processing and memory ability. Genes Brain Behav 13:802-11
Che, Alicia; Girgenti, Matthew J; LoTurco, Joseph (2014) The dyslexia-associated gene DCDC2 is required for spike-timing precision in mouse neocortex. Biol Psychiatry 76:387-96
Centanni, T M; Booker, A B; Sloan, A M et al. (2014) Knockdown of the dyslexia-associated gene Kiaa0319 impairs temporal responses to speech stimuli in rat primary auditory cortex. Cereb Cortex 24:1753-66
Siddiqi, Faez; Chen, Fuyi; Aron, Abraham W et al. (2014) Fate mapping by piggyBac transposase reveals that neocortical GLAST+ progenitors generate more astrocytes than Nestin+ progenitors in rat neocortex. Cereb Cortex 24:508-20

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