RISK GENES AND ENVIRONMENT INTERACTIONS IN NTDS ADMINISTRATIVE CORE: ABSTRACT Core A provides an anchor for the Program, assisting in grant administration and budget management as well as preparation of annual reports. It organizes annual meetings of the Internal and External Advisory faculty with Program investigators. Internal Advisory Board meetings will take place in Manhattan, while yearly External Advisory Board meetings will take place alternately in NY or TX. The Core will continue to schedule the monthly meetings of the project participants, which take place via videoconferencing and at times with in person participation of TX and OR members. It will organize and administratively support the periodic meetings in NY of Program investigators with those from TX and OR sites. Core A will coordinate training opportunities for Program investigators (students, postdocs, faculty). It will support collaborative experiments across Projects by facilitating the shipment of materials between NY, TX and OR. It will serve as the administrative link between the WCMC Genome Resources Core Facility (GRCF), the NY Genome Center and the laboratories at WCMC in New York, the University of Texas at Austin, Dell Pediatric Research Institute, and Oregon Health & Science University, Department of Genetics. These activities will continue to ensure the cohesiveness of this highly integrated Program.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD067244-10
Application #
9931245
Study Section
Special Emphasis Panel (ZHD1)
Project Start
Project End
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
10
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Type
DUNS #
060217502
City
New York
State
NY
Country
United States
Zip Code
10065
Dong, Yuqi; Wang, Linlin; Lei, Yunping et al. (2018) Gene variants in the folate pathway are associated with increased levels of folate receptor autoantibodies. Birth Defects Res 110:973-981
Sindelar, Miriam; Dyke, Jonathan P; Deeb, Ruba S et al. (2018) Untargeted Metabolite Profiling of Cerebrospinal Fluid Uncovers Biomarkers for Severity of Late Infantile Neuronal Ceroid Lipofuscinosis (CLN2, Batten Disease). Sci Rep 8:15229
Chen, Zhongzhong; Lei, Yunping; Zheng, Yufang et al. (2018) Threshold for neural tube defect risk by accumulated singleton loss-of-function variants. Cell Res 28:1039-1041
Wang, Linlin; Xiao, Yanhui; Tian, Tian et al. (2018) Digenic variants of planar cell polarity genes in human neural tube defect patients. Mol Genet Metab 124:94-100
Kim, Jimi; Lei, Yunping; Guo, Jin et al. (2018) Formate rescues neural tube defects caused by mutations in Slc25a32. Proc Natl Acad Sci U S A 115:4690-4695
Gao, Xiaoya; Finnell, Richard H; Wang, Hongyan et al. (2018) Network correlation analysis revealed potential new mechanisms for neural tube defects beyond folic acid. Birth Defects Res 110:982-993
Avagliano, Laura; Massa, Valentina; George, Timothy M et al. (2018) Overview on neural tube defects: From development to physical characteristics. Birth Defects Res :
Chen, Zhongzhong; Lei, Yunping; Cao, Xuanye et al. (2018) Genetic analysis of Wnt/PCP genes in neural tube defects. BMC Med Genomics 11:38
Sudarov, Anamaria; Zhang, Xin-Jun; Braunstein, Leighton et al. (2018) Mature Hippocampal Neurons Require LIS1 for Synaptic Integrity: Implications for Cognition. Biol Psychiatry 83:518-529
Chen, Zhongzhong; Kuang, Lele; Finnell, Richard H et al. (2018) Genetic and functional analysis of SHROOM1-4 in a Chinese neural tube defect cohort. Hum Genet 137:195-202

Showing the most recent 10 out of 54 publications