The Administrative Core is the operational center behind the entire P01 program. The Core will facilitate the research goals of the program by: * providing the organizational and administrative structure that insures maximally efficient use of resources among all investigators, * providing a centralized location for the tracking of expenditures and compilation of budgets, * insuring optimal dissemination of information among all investigators, * overseeing usage of the Tissue Repository Core to insure efficient distribution of human, macaque and rat tissues to all investigators, * directing usage of the Tissue Repository Core so that minimal numbers of animals are utilized, * funding new pilot projects in promising areas of research that complement the existing P01 projects while also opening additional avenues of research collaboration or expertise, arranging and coordinating the annual scientific retreat for the P01 program investigators, * assisting with the preparation and submission of manuscripts reporting P01 program scientific advances and also providing for page charges to support publication of these manuscripts * interacting with NICHD and the Office of Sponsored Projects Administration at the University of Kentucky to ensure compliance with all federal regulations * insuring that each scientific project maintains regulatory compliance by coordinating and accounting for all aspects of personnel training, protocol submission, approval, revision, and continuing review, (IACUC, recombinant DNA, biohazardous materials)

Public Health Relevance

The Administrative core is responsible for carefully and closely monitoring the entire operation of the P01 program, which is a multi-institutional program with 6 investigators at 3 different Universities. This core is the command central that deals with the day to day problems as well as insures that the long term research goals of the program are achieved.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Program Projects (P01)
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Special Emphasis Panel (ZHD1-DRG-D (41))
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University of Kentucky
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Lee-Thacker, Somang; Choi, Yohan; Taniuchi, Ichiro et al. (2018) Core Binding Factor ? Expression in Ovarian Granulosa Cells Is Essential for Female Fertility. Endocrinology 159:2094-2109
Hannon, Patrick R; Duffy, Diane M; Rosewell, Katherine L et al. (2018) Ovulatory Induction of SCG2 in Human, Nonhuman Primate, and Rodent Granulosa Cells Stimulates Ovarian Angiogenesis. Endocrinology 159:2447-2458
Bender, Hannah R; Trau, Heidi A; Duffy, Diane M (2018) Placental Growth Factor Is Required for Ovulation, Luteinization, and Angiogenesis in Primate Ovulatory Follicles. Endocrinology 159:710-722
Choi, Yohan; Rosewell, Katherine L; Brännström, Mats et al. (2018) FOS, a Critical Downstream Mediator of PGR and EGF Signaling Necessary for Ovulatory Prostaglandins in the Human Ovary. J Clin Endocrinol Metab 103:4241-4252
Choi, Yohan; Park, Ji Yeon; Wilson, Kalin et al. (2017) The expression of CXCR4 is induced by the luteinizing hormone surge and mediated by progesterone receptors in human preovulatory granulosa cells. Biol Reprod 96:1256-1266
Choi, Yohan; Wilson, Kalin; Hannon, Patrick R et al. (2017) Coordinated Regulation Among Progesterone, Prostaglandins, and EGF-Like Factors in Human Ovulatory Follicles. J Clin Endocrinol Metab 102:1971-1982
Kim, Soon Ok; Trau, Heidi A; Duffy, Diane M (2017) Vascular endothelial growth factors C and D may promote angiogenesis in the primate ovulatory follicle. Biol Reprod 96:389-400
Cacioppo, Joseph A; Lin, Po-Ching Patrick; Hannon, Patrick R et al. (2017) Granulosa cell endothelin-2 expression is fundamental for ovulatory follicle rupture. Sci Rep 7:817
Park, Chan Jin; Chen, Guanglin; Koo, Yongbum et al. (2017) Generation and characterization of an estrogen receptor alpha-iCre knock-in mouse. Genesis 55:
Li, Fei-Xue; Yu, Jiao-Jiao; Liu, Ying et al. (2017) Induction of Ectonucleotide Pyrophosphatase/Phosphodiesterase 3 During the Periovulatory Period in the Rat Ovary. Reprod Sci 24:1033-1040

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