Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL025830-18
Application #
6109570
Study Section
Project Start
1998-09-01
Project End
1999-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
18
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Prabhakar, Nanduri R; Semenza, Gregg L (2012) Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. Physiol Rev 92:967-1003
Kline, David D (2010) Chronic intermittent hypoxia affects integration of sensory input by neurons in the nucleus tractus solitarii. Respir Physiol Neurobiol 174:29-36
Peng, Y-J; Nanduri, J; Yuan, G et al. (2009) NADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia. J Neurosci 29:4903-10
Kline, David D; Hendricks, Gabriel; Hermann, Gerlinda et al. (2009) Dopamine inhibits N-type channels in visceral afferents to reduce synaptic transmitter release under normoxic and chronic intermittent hypoxic conditions. J Neurophysiol 101:2270-8
Prabhakar, Nanduri R; Kumar, Ganesh K; Nanduri, Jayasri (2009) Intermittent hypoxia-mediated plasticity of acute O2 sensing requires altered red-ox regulation by HIF-1 and HIF-2. Ann N Y Acad Sci 1177:162-8
Braga, Valdir A; Prabhakar, Nanduri R (2009) Refinement of telemetry for measuring blood pressure in conscious rats. J Am Assoc Lab Anim Sci 48:268-71
Kline, David D (2008) Plasticity in glutamatergic NTS neurotransmission. Respir Physiol Neurobiol 164:105-11
Buniel, Maria; Glazebrook, Patricia A; Ramirez-Navarro, Angelina et al. (2008) Distribution of voltage-gated potassium and hyperpolarization-activated channels in sensory afferent fibers in the rat carotid body. J Comp Neurol 510:367-77
Pawar, Anita; Peng, Ying-Jie; Jacono, Frank J et al. (2008) Comparative analysis of neonatal and adult rat carotid body responses to chronic intermittent hypoxia. J Appl Physiol 104:1287-94
Hsieh, Yee-Hsee; Dick, Thomas E; Siegel, Ruth E (2008) Adaptation to hypobaric hypoxia involves GABA A receptors in the pons. Am J Physiol Regul Integr Comp Physiol 294:R549-57

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