The overarching objective of this Project is to study genetic variants and environmental factors that act, whether interactively or independently to influence the expression of a wide range of psychosocial, behavioral and biological characteristics that increase the risk of developing CVD and Type 2 Diabetes, a major CVD risk factor, among healthy persons in Wave IV of the National Longitudinal Study of Adolescent Health. We will both replicate previous findings from Project 1 and generate new hypotheses from this data set. In particular, we will study the race and gender associations of a broad range of CVD endophenotypes to identify promising candidate gene polymorphisms that are associated with risky health behaviors, psychosocial risk factors, and dysregulated neuroendocrine, autonomic, cardiovascular, metabolic, and inflammatory functions and model the gene by environment interactions.

Public Health Relevance

The knowledge gained in Project 2 will constitute important progress toward the long range goal of being able to identify persons at risk of developing CVD or type2 diabetes eariier in the pathogenic process, so that they, and the CVD endophenotypes accounting for their increased risk, can be targeted for preventive interventions, to prevent the development of disease to all members of the US population.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL036587-24
Application #
8644125
Study Section
Special Emphasis Panel (ZHL1)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
24
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Duke University
Department
Type
DUNS #
City
Durham
State
NC
Country
United States
Zip Code
27705
Singh, Abanish; Babyak, Michael A; Brummett, Beverly H et al. (2018) Developing a synthetic psychosocial stress measure and harmonizing CVD-risk data: a way forward to GxE meta- and mega-analyses. BMC Res Notes 11:504
Ward-Caviness, Cavin K; Kraus, William E; Blach, Colette et al. (2018) Associations Between Residential Proximity to Traffic and Vascular Disease in a Cardiac Catheterization Cohort. Arterioscler Thromb Vasc Biol 38:275-282
Mirowsky, Jaime E; Devlin, Robert B; Diaz-Sanchez, David et al. (2017) A novel approach for measuring residential socioeconomic factors associated with cardiovascular and metabolic health. J Expo Sci Environ Epidemiol 27:281-289
Williams, Redford B; Bishop, George D; Haberstick, Brett C et al. (2017) Population differences in associations of serotonin transporter promoter polymorphism (5HTTLPR) di- and triallelic genotypes with blood pressure and hypertension prevalence. Am Heart J 185:110-122
Jiang, Rong; Babyak, Michael A; Brummett, Beverly H et al. (2017) Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism interacts with gender to influence cortisol responses to mental stress. Psychoneuroendocrinology 79:13-19
Jiang, Rong; Babyak, Michael A; Brummett, Beverly H et al. (2017) Brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism is associated with disease severity and incidence of cardiovascular events in a patient cohort. Am Heart J 190:40-45
Haberstick, Brett C; Boardman, Jason D; Wagner, Brandon et al. (2016) Depression, Stressful Life Events, and the Impact of Variation in the Serotonin Transporter: Findings from the National Longitudinal Study of Adolescent to Adult Health (Add Health). PLoS One 11:e0148373
Ward-Caviness, Cavin K; Neas, Lucas M; Blach, Colette et al. (2016) Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease. PLoS One 11:e0152670
McGarrah, Robert W; Craig, Damian M; Haynes, Carol et al. (2016) High-density lipoprotein subclass measurements improve mortality risk prediction, discrimination and reclassification in a cardiac catheterization cohort. Atherosclerosis 246:229-35
Ogle, Christin M; Rubin, David C; Siegler, Ilene C (2016) Accounting for Posttraumatic Stress Disorder Symptom Severity With Pre- and Posttrauma Measures: A Longitudinal Study of Older Adults. Clin Psychol Sci 4:272-286

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