Program administration is centralized in Core A to promote synergistic interaction between clinical and laboratory projects and to provide strong leadership for the Program. As described in the Program Introduction, Dr. Sorrentino, the Program Principal Investigator, has primary responsibility for the overall coordination of the Program Project, including the three projects and four core components. The Administration Core will provide key functions to assist Dr. Sorrentino in guiding and supervising this Program. One such function will be organizing the Hematology Research Seminar Series, which meets every two weeks and includes all academic personnel that participate in the Program. The Administration Core will also provide support for our External Advisory Committee, which will travel to St. Jude once a year in years 2-5 in order to review our progress and critique the projects and cores. This Core will provide general administrative support for the program including assistance in preparing and submitting yearly non-competitive renewals, assist in preparation of manuscripts, and provide for travel arrangements for Project and Core leaders to travel to scientific meetings and present their results. The Administration Core will also provide for budgetary oversight, ordering of supplies, provide administrative oversight for the subcontracts in this Program, and provide with general secretarial support for the Project and Core leaders.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
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Heart, Lung, and Blood Initial Review Group (HLBP)
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St. Jude Children's Research Hospital
United States
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Zhao, Hui Fen; Abraham, Allistair; Kim, Yoon-Sang et al. (2017) Lentiviral Transfer of ?-Globin with Fusion Gene NUP98-HOXA10HD Expands Hematopoietic Stem Cells and Ameliorates Murine ?-Thalassemia. Mol Ther 25:593-605
De Ravin, Suk See; Wu, Xiaolin; Moir, Susan et al. (2016) Lentiviral hematopoietic stem cell gene therapy for X-linked severe combined immunodeficiency. Sci Transl Med 8:335ra57
Abraham, Allistair; Kim, Yoon-Sang; Zhao, Huifen et al. (2016) Increased Engraftment of Human Short Term Repopulating Hematopoietic Cells in NOD/SCID/IL2r?null Mice by Lentiviral Expression of NUP98-HOXA10HD. PLoS One 11:e0147059
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Zhou, Sheng; Bonner, Melissa A; Wang, Yong-Dong et al. (2015) Quantitative shearing linear amplification polymerase chain reaction: an improved method for quantifying lentiviral vector insertion sites in transplanted hematopoietic cell systems. Hum Gene Ther Methods 26:4-12
Urbinati, Fabrizia; Hargrove, Phillip W; Geiger, Sabine et al. (2015) Potentially therapeutic levels of anti-sickling globin gene expression following lentivirus-mediated gene transfer in sickle cell disease bone marrow CD34+ cells. Exp Hematol 43:346-351
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Nasimuzzaman, Md; Kim, Yoon-Sang; Wang, Yong-Dong et al. (2014) High-titer foamy virus vector transduction and integration sites of human CD34(+) cell-derived SCID-repopulating cells. Mol Ther Methods Clin Dev 1:14020

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