The application of murine molecular genetics (including transgenic and chimeric approaches) and physiologic (and pathophysiologic) analysis of murine models of disease is a major feature of all of the Projects in this Program. All of the Projects require a great deal of complex breeding of mice, involving genotyping and tracking multiple genes. Furthermore, there are multiple common murine physiologic methods used throughout the Program. The Murine Genetics and Physiology Core will be invaluable in streamlining and making available in the most cost-effective manner these approaches to all of the Projects.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL066105-10
Application #
8113150
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
2013-06-30
Budget Start
2010-07-01
Budget End
2013-06-30
Support Year
10
Fiscal Year
2010
Total Cost
$511,299
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Murphy, Patrick A; Butty, Vincent L; Boutz, Paul L et al. (2018) Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow. Elife 7:
Alvarez-Dominguez, Juan R; Knoll, Marko; Gromatzky, Austin A et al. (2017) The Super-Enhancer-Derived alncRNA-EC7/Bloodlinc Potentiates Red Blood Cell Development in trans. Cell Rep 19:2503-2514
Alvarez-Dominguez, Juan R; Lodish, Harvey F (2017) Emerging mechanisms of long noncoding RNA function during normal and malignant hematopoiesis. Blood 130:1965-1975
Dockendorff, Chris; Faloon, Patrick W; Germain, Andrew et al. (2015) Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake. Bioorg Med Chem Lett 25:2594-8
Turner, Christopher J; Badu-Nkansah, Kwabena; Crowley, Denise et al. (2015) ?5 and ?v integrins cooperate to regulate vascular smooth muscle and neural crest functions in vivo. Development 142:797-808
Alvarez-Dominguez, Juan R; Bai, Zhiqiang; Xu, Dan et al. (2015) De Novo Reconstruction of Adipose Tissue Transcriptomes Reveals Long Non-coding RNA Regulators of Brown Adipocyte Development. Cell Metab 21:764-776
Dockendorff, Chris; Faloon, Patrick W; Pu, Jun et al. (2015) Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake. Bioorg Med Chem Lett 25:2100-5
Murphy, Patrick A; Begum, Shahinoor; Hynes, Richard O (2015) Tumor angiogenesis in the absence of fibronectin or its cognate integrin receptors. PLoS One 10:e0120872
Alvarez-Dominguez, Juan R; Hu, Wenqian; Yuan, Bingbing et al. (2014) Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation. Blood 123:570-81
Hu, Wenqian; Yuan, Bingbing; Lodish, Harvey F (2014) Cpeb4-mediated translational regulatory circuitry controls terminal erythroid differentiation. Dev Cell 30:660-72

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