The Core B (Animal Model Core) for the MCW P01 program project grant, entitled ?Renal Mechanisms in Blood Pressure Control?, will support program project investigators with comprehensive management of several novel genetically engineered rat models. The need for Core B is apparent considering current heavy use of rat models and the numbers of animals proposed. Throughout the history of the PPG, Core B has provided a centralized approach to managing rat models to achieve the proposed studies. The overall goal of Core B is to assist program project investigators with the development, management, genotyping, distribution, and molecular characterization of the models. Multiple approaches will be available to develop new models as needed by the Project investigators. Core B will serve as an invaluable resource for the project investigators to define the novel mechanisms that lead to the control of blood pressure and kidney diseases. Core staff will also assist in experimental design and training of the laboratory staff, and participate in data collection, analysis, and preparation for publication.

Public Health Relevance

Animal Model Core B is an essential component of this grant and will support all three projects of this PPG. The three scientific projects share the common goal of providing novel insights into the mechanisms and functional pathways underlying the development of salt-sensitive hypertension and renal damage. The overall goal of Core B is to manage, genotype distribute, and assist in the molecular characterization of several genetically modified rat strains necessary to conduct the proposed studies.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL116264-08
Application #
9841971
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Program Officer
OH, Youngsuk
Project Start
Project End
Budget Start
2020-01-01
Budget End
2020-12-31
Support Year
8
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Medical College of Wisconsin
Department
Type
DUNS #
937639060
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Mattson, David L (2018) Heat stress nephropathy and hyperuricemia. Am J Physiol Renal Physiol 315:F757-F758
Abais-Battad, Justine M; Lund, Hayley; Fehrenbach, Daniel J et al. (2018) Rag1-null Dahl SS rats reveal that adaptive immune mechanisms exacerbate high protein-induced hypertension and renal injury. Am J Physiol Regul Integr Comp Physiol 315:R28-R35
Bukowy, John D; Dayton, Alex; Cloutier, Dustin et al. (2018) Do computers dream of electric glomeruli? Kidney Int 94:635
Spires, Denisha; Ilatovskaya, Daria V; Levchenko, Vladislav et al. (2018) Protective role of Trpc6 knockout in the progression of diabetic kidney disease. Am J Physiol Renal Physiol 315:F1091-F1097
Bukowy, John D; Dayton, Alex; Cloutier, Dustin et al. (2018) Region-Based Convolutional Neural Nets for Localization of Glomeruli in Trichrome-Stained Whole Kidney Sections. J Am Soc Nephrol 29:2081-2088
Regal, Jean F; Laule, Connor F; McCutcheon, Luke et al. (2018) The complement system in hypertension and renal damage in the Dahl SS rat. Physiol Rep 6:e13655
Abais-Battad, Justine M; Lund, Hayley; Fehrenbach, Daniel J et al. (2018) Parental Dietary Protein Source and the Role of CMKLR1 in Determining the Severity of Dahl Salt-Sensitive Hypertension. Hypertension :HYPERTENSIONAHA11811994
Williams, Anna Marie; Liu, Yong; Regner, Kevin R et al. (2018) Artificial intelligence, physiological genomics, and precision medicine. Physiol Genomics 50:237-243
Palygin, Oleg; Miller, Bradley S; Nishijima, Yoshinori et al. (2018) Endothelin receptor A and p66Shc regulate spontaneous Ca2+ oscillations in smooth muscle cells controlling renal arterial spontaneous motion. FASEB J :fj201800776RR
Wade, Brittany; Petrova, Galina; Mattson, David L (2018) Role of immune factors in angiotensin II-induced hypertension and renal damage in Dahl salt-sensitive rats. Am J Physiol Regul Integr Comp Physiol 314:R323-R333

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