Abstract

The Retrovirus SIV/macaque Database was developed by Drs Mankowski and Tarwater to facilitate acquisition of the large quantity of data generated by the projects in the original CNS &Peripheral Reservoirs in SIV Model of HIV HAART Program Project Grant. It now includes over 300 SIV-infected and uninfected macaques, including over 250 pigtailed macaques inoculated under our dual infection protocol (accelerated, consistent model of SIV) and thus serves as the central repository for all virologic, immunologic, and pathologic measurements from all animals on study in the Retrovirus Lab over the last ten years. All data from the studies in this proposal will be added to the existing database, thereby integrating the data sets from past and prospective studies including all HAART-treated animals.
Aim 1 of this core encompasses the data management of all program projects to insure the accurate acquisition and efficient entry of all project data into our master database to facilitate investigator access.
Aim 2 of this core is to facilitate data analysis to provide advanced statistical analysis support for all investigators and research staff for each project and the entire integrated program using data compiled in the SIV/macaque master database.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Program Projects (P01)
Project #
5P01MH070306-10
Application #
8582573
Study Section
Special Emphasis Panel (ZMH1-ERB-F)
Project Start
Project End
2015-11-30
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
10
Fiscal Year
2014
Total Cost
$128,552
Indirect Cost
$68,028

  Institution

Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Beck, Sarah E; Queen, Suzanne E; Metcalf Pate, Kelly A et al. (2018) An SIV/macaque model targeted to study HIV-associated neurocognitive disorders. J Neurovirol 24:204-212
Croteau, Joshua D; Engle, Elizabeth L; Queen, Suzanne E et al. (2017) Marked Enteropathy in an Accelerated Macaque Model of AIDS. Am J Pathol 187:589-604
Gannon, Patrick J; Akay-Espinoza, Cagla; Yee, Alan C et al. (2017) HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via ?-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation. Am J Pathol 187:91-109
Gama, Lucio; Abreu, Celina M; Shirk, Erin N et al. (2017) Reactivation of simian immunodeficiency virus reservoirs in the brain of virally suppressed macaques. AIDS 31:5-14
Williams, Dionna W; Engle, Elizabeth L; Shirk, Erin N et al. (2016) Splenic Damage during SIV Infection: Role of T-Cell Depletion and Macrophage Polarization and Infection. Am J Pathol 186:2068-2087
Saylor, Deanna; Dickens, Alex M; Sacktor, Ned et al. (2016) HIV-associated neurocognitive disorder--pathogenesis and prospects for treatment. Nat Rev Neurol 12:234-48
Mangus, Lisa M; Dorsey, Jamie L; Weinberg, Rachel L et al. (2016) Tracking Epidermal Nerve Fiber Changes in Asian Macaques: Tools and Techniques for Quantitative Assessment. Toxicol Pathol 44:904-12
Avalos, Claudia R; Price, Sarah L; Forsyth, Ellen R et al. (2016) Quantitation of Productively Infected Monocytes and Macrophages of Simian Immunodeficiency Virus-Infected Macaques. J Virol 90:5643-5656
Beck, Sarah E; Queen, Suzanne E; Viscidi, Raphael et al. (2016) Central nervous system-specific consequences of simian immunodeficiency virus Gag escape from major histocompatibility complex class I-mediated control. J Neurovirol 22:498-507
Drewes, Julia L; Meulendyke, Kelly A; Liao, Zhaohao et al. (2015) Quinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART. J Neurovirol 21:449-63

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