The Administrative and Biostatistics Core (A) is responsible for the coordination of all scientific, fiscal, educational, and quality control activities of the Center. The administrative structure of the Core includes an External Monitoring Committee that meets annually, an Internal Monitoring Committee that meets quarterly, and a monthly meeting of the Center Director with all Primary Investigators. The monthly meetings have been held since 1991 and have been an excellent forum for the critical discussion of individual research projects, planning of future research, resolving budgetary issues, and integrating our clinical and basic science research efforts. The Core also is responsible for the national and international dissemination of our activities via the Brain Trauma Research Center Website. The Core will continue to coordinate productive collaborations of the BTRC investigators with investigations in The Center for Injury Research and Control (Hank Weiss, Ph.D, Center Director), The Safar Center for Resuscitation Research (Patrick Kochanek, M.D., Center Director), The Epidemiology Data Center (Stephen Wisniewski, Ph.D.), The Benedum Pediatric Trauma Program (P. David Adelson, M.D., Center Director), The NCMRR/NICHD Traumatic Brain Injury Clinical Trials (TBI-CT) Network, Carnegie Mellon University, and the Alzheimer Disease Research Center.(Steven DeKosky, M.D., Center Director) thereby facilitating the development of new avenues of research. We have found that such collaborative research can be accompanied with extraordinary efficiency because of this overlap of interests of the funded investigators in these centers. An essential focus of this Core and of all the Primary Investigators has been the conduct of high quality research leading to meaningful and statistically valid results. In the preparation of this Program Project, we have placed particular emphasis on the biostatistical development and analysis of the data collected in the five primary projects. Stephen Wisniewski, Ph.D., Co-Director of this Core, has worked closely with each of the five Primary Investigators to guide the determination of sample sizes and advise on appropriateness of the specific statistical analyses proposed. He and his team at the Epidemiology Data Center will review all major scientific findings of our Center, and will edit all manuscripts for appropriateness of statistical analysis and conclusions prior to journal submission.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Program Projects (P01)
Project #
Application #
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pittsburgh
United States
Zip Code
Markos, Steven M; Failla, Michelle D; Ritter, Anne C et al. (2017) Genetic Variation in the Vesicular Monoamine Transporter: Preliminary Associations With Cognitive Outcomes After Severe Traumatic Brain Injury. J Head Trauma Rehabil 32:E24-E34
Ikonomovic, Milos D; Mi, Zhiping; Abrahamson, Eric E (2017) Disordered APP metabolism and neurovasculature in trauma and aging: Combined risks for chronic neurodegenerative disorders. Ageing Res Rev 34:51-63
Jackson, Edwin K; Kotermanski, Shawn E; Menshikova, Elizabeth V et al. (2017) Adenosine production by brain cells. J Neurochem 141:676-693
Kumar, Raj G; Rubin, Jonathan E; Berger, Rachel P et al. (2016) Principal components derived from CSF inflammatory profiles predict outcome in survivors after severe traumatic brain injury. Brain Behav Immun 53:183-193
Santarsieri, M; Kumar, R G; Kochanek, P M et al. (2015) Variable neuroendocrine-immune dysfunction in individuals with unfavorable outcome after severe traumatic brain injury. Brain Behav Immun 45:15-27
Gandy, Sam; Ikonomovic, Milos D; Mitsis, Effie et al. (2014) Chronic traumatic encephalopathy: clinical-biomarker correlations and current concepts in pathogenesis. Mol Neurodegener 9:37
Alexander, Sheila A; Ren, Dianxu; Gunn, Scott R et al. (2014) Interleukin 6 and apolipoprotein E as predictors of acute brain dysfunction and survival in critical care patients. Am J Crit Care 23:49-57
Yan, Hong Q; Shin, Samuel S; Ma, Xiecheng et al. (2014) Differential effect of traumatic brain injury on the nuclear factor of activated T Cells C3 and C4 isoforms in the rat hippocampus. Brain Res 1548:63-72
Nwachuku, Enyinna L; Puccio, Ava M; Fetzick, Anita et al. (2014) Intermittent versus continuous cerebrospinal fluid drainage management in adult severe traumatic brain injury: assessment of intracranial pressure burden. Neurocrit Care 20:49-53
Diamond, Matthew L; Ritter, Anne C; Failla, Michelle D et al. (2014) IL-1? associations with posttraumatic epilepsy development: a genetics and biomarker cohort study. Epilepsia 55:1109-19

Showing the most recent 10 out of 71 publications