Core A - Administrative and Statistics Core The Administrative and Statistics Core will provide administrative, statistical, and data sharing support for all Projects and Cores. The Program Project Grant will be administered through the Neurology Department at Washington University. Project Director Dr. Cross will be responsible for overall performance of the Program. Day-to-day scientific and budgetary management of each Project or Core will be delegated to the individual Principle Investigators. Collectively, this group of Project and Core Principle Investigators will constitute the Program Project Executive Committee. Biostatistician Dr. Trinkaus will work with Dr. Cross to review data from all Projects and Cores, and will be available to provide guidance regarding experimental design and statistical analyses to all Project investigators. She will attend all group meetings, and will aid in development of the PO1 database. Dr. Alpay Ozcan will work with us to develop a computerized database and data sharing system for the PO1. The Administrative Core will employ an administrative assistant (50% effort) supervised by the PI. Dr. Trinkaus, faculty statistician, will direct Biostatistics within Core A. Drs. Cross and Trinkaus will meet monthly with members of the Program Executive Committee to coordinate research activities and resource allocation. The Project Director will also arrange regular input from the Internal Scientific Advisory Board. A meeting involving the Internal Advisory Board and all investigators in which progress is shared with the Board will occur 3-4 times/year. The PO1 Directors will encourage the prompt publication of all research results. The administrative core will also coordinate data sharing in accordance with NINDS standards.

Public Health Relevance

TO PUBLIC HEALTH: The administrative and statistical core is responsible for coordinating the Program Project Grant research projects and core activities. Core A provides administrative, statistical, and computer support for all other components. Core A is responsible for ensuring that scientific discoveries made in the Program Project are disseminated via timely research publication and data sharing.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Program Projects (P01)
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National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
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Washington University
Saint Louis
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Agner, Shannon C; Klein, Robyn S (2018) Viruses have multiple paths to central nervous system pathology. Curr Opin Neurol 31:313-317
Adusumilli, Gautam; Trinkaus, Kathryn; Sun, Peng et al. (2018) Intensity ratio to improve black hole assessment in multiple sclerosis. Mult Scler Relat Disord 19:140-147
Spees, William M; Lin, Tsen-Hsuan; Sun, Peng et al. (2018) MRI-based assessment of function and dysfunction in myelinated axons. Proc Natl Acad Sci U S A 115:E10225-E10234
Zhan, Jie; Lin, Tsen-Hsuan; Libbey, Jane E et al. (2018) Diffusion Basis Spectrum and Diffusion Tensor Imaging Detect Hippocampal Inflammation and Dendritic Injury in a Virus-Induced Mouse Model of Epilepsy. Front Neurosci 12:77
Klein, Robyn S; Garber, Charise; Howard, Nicole (2017) Infectious immunity in the central nervous system and brain function. Nat Immunol 18:132-141
Lin, Tsen-Hsuan; Chiang, Chia-Wen; Perez-Torres, Carlos J et al. (2017) Diffusion MRI quantifies early axonal loss in the presence of nerve swelling. J Neuroinflammation 14:78
Cross, Anne H; Song, Sheng-Kwei (2017) ""A new imaging modality to non-invasively assess multiple sclerosis pathology"". J Neuroimmunol 304:81-85
Klein, Robyn S; Hunter, Christopher A (2017) Protective and Pathological Immunity during Central Nervous System Infections. Immunity 46:891-909
Hou, Jianghui; Baker, Lane A; Zhou, Lushan et al. (2016) Viral interactions with the blood-brain barrier: old dog, new tricks. Tissue Barriers 4:e1142492
Salimi, Hamid; Cain, Matthew D; Klein, Robyn S (2016) Encephalitic Arboviruses: Emergence, Clinical Presentation, and Neuropathogenesis. Neurotherapeutics 13:514-34

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