The Administrative and Statistics Core will continue to provide administrative, statistical, and data sharing support for all Projects and Cores. The Program Project Grant (PPG) will be administered through the Neurology Dept at Washington Univ. Director Dr. Cross will be responsible for overall performance of the PPG. Day-to-day scientific and budgetary management of each Project or Core will be delegated to individual Principle Investigators (PIs). Investigators involved in the PPG will meet monthly for a """"""""work in progress"""""""" scientific meeting. The Project PIs, Drs. Cross, Robyn Klein, Sheng-Kwei Song, and biostatistician Kathryn Trinkaus will constitute the Program Project Executive Committee, who will meet monthly to coordinate research activities and resource allocation. One or more outside speakers will be invited to address the group yearly. Dr. Trinkaus will direct Biostatistics within Core A and will work with Dr. Cross to review data from all Projects and Cores. Dr. Trinkaus will be available to provide guidance regarding experimental design and statistical analyses to all Project investigators. As a member of the Executive Committee Dr. Trinkaus will attend all group meetings, and will aid in maintenance of the PO1 database, begun during the first 5 years. She will help maintain our computerized system of data sharing within the PPG, in accordance with NINDS standards. Dr. Trinkaus is critical to the success of all six Projects and Cores, and thus will devote 3.0 cal mo (25% effort). The PPG Director will encourage the prompt publication of all research results. The Administrative Core will employ an administrative assistant (14% effort/1.73 cal mos) supervised by the PI. This will continue to be Nanette Bladdick. Dr. Cross will arrange regular input from the Internal Scientific Advisory Board. Progress of the PO1 will be shared with this Advisory Board at least yearly.

Public Health Relevance

Core A is responsible for coordinating the PPG research projects and other Core activities by providing administrative, biostatistical, and computer support for all PPG components. Core A is responsible for ensuring that scientific discoveries made in the PPG are disseminated via timely research publications and data sharing so that our research can be used to improve Public Health.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Program Projects (P01)
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National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
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Washington University
Saint Louis
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Agner, Shannon C; Klein, Robyn S (2018) Viruses have multiple paths to central nervous system pathology. Curr Opin Neurol 31:313-317
Adusumilli, Gautam; Trinkaus, Kathryn; Sun, Peng et al. (2018) Intensity ratio to improve black hole assessment in multiple sclerosis. Mult Scler Relat Disord 19:140-147
Spees, William M; Lin, Tsen-Hsuan; Sun, Peng et al. (2018) MRI-based assessment of function and dysfunction in myelinated axons. Proc Natl Acad Sci U S A 115:E10225-E10234
Zhan, Jie; Lin, Tsen-Hsuan; Libbey, Jane E et al. (2018) Diffusion Basis Spectrum and Diffusion Tensor Imaging Detect Hippocampal Inflammation and Dendritic Injury in a Virus-Induced Mouse Model of Epilepsy. Front Neurosci 12:77
Klein, Robyn S; Garber, Charise; Howard, Nicole (2017) Infectious immunity in the central nervous system and brain function. Nat Immunol 18:132-141
Lin, Tsen-Hsuan; Chiang, Chia-Wen; Perez-Torres, Carlos J et al. (2017) Diffusion MRI quantifies early axonal loss in the presence of nerve swelling. J Neuroinflammation 14:78
Cross, Anne H; Song, Sheng-Kwei (2017) ""A new imaging modality to non-invasively assess multiple sclerosis pathology"". J Neuroimmunol 304:81-85
Klein, Robyn S; Hunter, Christopher A (2017) Protective and Pathological Immunity during Central Nervous System Infections. Immunity 46:891-909
Hou, Jianghui; Baker, Lane A; Zhou, Lushan et al. (2016) Viral interactions with the blood-brain barrier: old dog, new tricks. Tissue Barriers 4:e1142492
Salimi, Hamid; Cain, Matthew D; Klein, Robyn S (2016) Encephalitic Arboviruses: Emergence, Clinical Presentation, and Neuropathogenesis. Neurotherapeutics 13:514-34

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