The Bioinformatics, Biostatistics, and Computational Biology Core (BBCC) of the Louisiana Biomedical Research Network (LBRN) serves to train and support project investigators and their teams across Louisiana, and to lead and support translational research activities at the frontiers of biomedical science. Its team uses both established and custom computational tools, operating at computational scales ranging from the mundane to analyses engaging many hundreds of compute cores. The BBCC is divided into four subunits, led by faculty and staff across four Louisiana campuses. The Cyberinfrastructure and Biomedical Data Analytics (CBDA) subunit supports the use of high performance computing (HPC) and the Louisiana Optical Network Initiative (LONI), and enables primarily undergraduate institution (PUI) investigators to conduct research engaging biomedical ?big data? (e.g., genome-scale sequence alignment). The Biomedical Data Mining and Biostatistics (BDMB) subunit focuses on creating advanced data mining algorithm solutions to analyze large biomedical and biological datasets. The Biomedical Visualization and Interaction (BVI) subunit enables display and interaction (including synchronous distributed interaction) with biomedical data, which is crucial to actionable engagement with large biomedical datasets. Finally, the Communications Infrastructure and Training (CIT) subunit, jointly operated with the Administrative Core and the Molecular and Cell Biology Resources Core, supports synchronous and asynchronous video communication across LBRN, including facilitating a variety of training activities. The BBCC and its subunits focus on three specific aims. First, led by CBDA with CIT contributions, BBCC will maintain and enhance the established cyberinfrastructure and provide computational resources expertise and support to all PUI campuses. Second, CBDA, BDMB, and BVI will equally contribute to provide bioinformatics, biostatistics, and computational biology services to PUI investigators, and leadership and support for translational biomedical research. Finally, with coordination by CIT, all BBCC personnel will collaborate to provide organized training and educational support in bioinformatics, biostatistics, and computational biology to LBRN PUI faculty, staff, and students. These training efforts include workshops, seminar broadcasts and archives, poster events, teleconferences, and ad hoc training.

Public Health Relevance

The Bioinformatics, Biostatistics, and Computational Biology Core (BBCC) serves to train and support project investigators and their teams across Louisiana. It is structured around four subunits that work together to enable Louisiana Biomedical Research Network (LBRN) project PIs and their teams to employ Louisiana cyberinfrastructure (especially high performance computing), and to provide bioinformatics services, training, and educational support.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
2P20GM103424-14
Application #
8899070
Study Section
Special Emphasis Panel (ZGM1-TWD-0 (IN))
Project Start
Project End
Budget Start
2015-05-01
Budget End
2016-04-30
Support Year
14
Fiscal Year
2015
Total Cost
$376,632
Indirect Cost
$99,961
Name
Louisiana State University A&M Col Baton Rouge
Department
Type
DUNS #
075050765
City
Baton Rouge
State
LA
Country
United States
Zip Code
70803
Fakhruddin, Selim; Alanazi, Wael A; Alhamami, Hussain N et al. (2018) Hyperglycaemia induced by chronic i.p. and oral glucose loading leads to hypertension through increased Na+ retention in proximal tubule. Exp Physiol 103:236-249
Kaur, Gagandeep; Bagam, Prathyusha; Pinkston, Rakeysha et al. (2018) Cigarette smoke-induced inflammation: NLRP10-mediated mechanisms. Toxicology 398-399:52-67
Al-Horani, Rami A; Afosah, Daniel K (2018) Recent advances in the discovery and development of factor XI/XIa inhibitors. Med Res Rev 38:1974-2023
Singh, Dhirendra P; Kaur, Gagandeep; Bagam, Prathyusha et al. (2018) Membrane microdomains regulate NLRP10- and NLRP12-dependent signalling in A549 cells challenged with cigarette smoke extract. Arch Toxicol 92:1767-1783
Mei, Suyu; Flemington, Erik K; Zhang, Kun (2018) Transferring knowledge of bacterial protein interaction networks to predict pathogen targeted human genes and immune signaling pathways: a case study on M. tuberculosis. BMC Genomics 19:505
Shen, Xinyu; Sun, Chun; Bai, Xue et al. (2018) Efficient and Stable CsPb(Br/I)3@Anthracene Composites for White Light-Emitting Devices. ACS Appl Mater Interfaces 10:16768-16775
Yin, Wenxu; Zhang, Xiaoyu; Bai, Xue et al. (2018) Low-Cost One-Pot Synthesis of WS2 Quantum Dots with Wide Emission Spectrum for Light-Emitting Applications. Chempluschem 83:1052-1056
Zhang, Wensheng; Flemington, Erik K; Zhang, Kun (2018) Driver gene mutations based clustering of tumors: methods and applications. Bioinformatics 34:i404-i411
Xue, Dingke; Ruan, Cheng; Zhang, Yu et al. (2018) Enhanced bandwidth of white light communication using nanomaterial phosphors. Nanotechnology 29:455708
Whitehead, Anna K; Barnett, Haley H; Caldorera-Moore, Mary E et al. (2018) Poly (ethylene glycol) hydrogel elasticity influences human mesenchymal stem cell behavior. Regen Biomater 5:167-175

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