(Administrative Core) The overall objective of the Administrative Core is to provide leadership and guidance to, and ensure efficient operation and management of, the Oklahoma COBRE in Structural Biology (OCSB) through effective oversight, fiscal responsibility and a transparent administrative infrastructure. The PI/PD Dr. West will direct the Administrative Core and is responsible for all administrative and reporting functions of the OCSB. She will be assisted by the Associate Program Director, Dr. Gillian Air, and a full-time administrative staff assistant who will help manage financial and coordination aspects of the center. An outstanding team of advisors (IAC, EAC) and mentors will monitor the progress of the project leaders and core facilities. The Administrative Core is responsible for several important activities including coordinating the activities of the OCSB, communication with the oversight committees (EAC, IAC and research core advisory committees) and mentors, preparation of progress reports, management of the pilot project program, and organization of the annual symposia and workshops.
The specific aims of the Administrative Core are to: 1) Provide an efficient administrative framework to oversee programmatic and financial management of the center; 2) Foster professional development of the investigators through an effective mentoring plan, clear expectations and evaluative feedback; 3) Continue to develop collaborative core facilities towards a self-sustaining future in support of structural biology researchers; and 4) Enhance the visibility of the OCSB and promote structural biology in the State through various outreach and educational activities.

Public Health Relevance

The Administrative Core of the Oklahoma COBRE in Structural Biology (OCSB) provides administrative support to the project leaders, pilot project program, and core facilities who are engaged in biomedically important research on human diseases and conditions associated with infectious bacteria, neurodegenerative diseases, heart disease, and cancer.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103640-09
Application #
9934236
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2020-06-01
Budget End
2021-05-31
Support Year
9
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Oklahoma Norman
Department
Type
DUNS #
848348348
City
Norman
State
OK
Country
United States
Zip Code
73019
Hebdon, Skyler D; Menon, Smita K; Richter-Addo, George B et al. (2018) Regulatory Targets of the Response Regulator RR_1586 from Clostridioides difficile Identified Using a Bacterial One-Hybrid Screen. J Bacteriol 200:
Cruz-Reyes, Jorge; Mooers, Blaine H M; Doharey, Pawan K et al. (2018) Dynamic RNA holo-editosomes with subcomplex variants: Insights into the control of trypanosome editing. Wiley Interdiscip Rev RNA 9:e1502
Booe, Jason M; Warner, Margaret L; Roehrkasse, Amanda M et al. (2018) Probing the Mechanism of Receptor Activity-Modifying Protein Modulation of GPCR Ligand Selectivity through Rational Design of Potent Adrenomedullin and Calcitonin Gene-Related Peptide Antagonists. Mol Pharmacol 93:355-367
Muthuramalingam, Meenakumari; White, John C; Murphy, Tamiko et al. (2018) The toxin from a ParDE toxin-antitoxin system found in Pseudomonas aeruginosa offers protection to cells challenged with anti-gyrase antibiotics. Mol Microbiol :
Roehrkasse, Amanda M; Booe, Jason M; Lee, Sang-Min et al. (2018) Structure-function analyses reveal a triple ?-turn receptor-bound conformation of adrenomedullin 2/intermedin and enable peptide antagonist design. J Biol Chem 293:15840-15854
Van Orden, Mason J; Klein, Peter; Babu, Kesavan et al. (2017) Conserved DNA motifs in the type II-A CRISPR leader region. PeerJ 5:e3161
Murugan, Karthik; Babu, Kesavan; Sundaresan, Ramya et al. (2017) The Revolution Continues: Newly Discovered Systems Expand the CRISPR-Cas Toolkit. Mol Cell 68:15-25
Li, Yangxiong; Lavey, Nathan P; Coker, Jesse A et al. (2017) Consequences of Depsipeptide Substitution on the ClpP Activation Activity of Antibacterial Acyldepsipeptides. ACS Med Chem Lett 8:1171-1176
Wang, Bing; Powell, Samantha M; Guan, Ye et al. (2017) Nitrosoamphetamine binding to myoglobin and hemoglobin: Crystal structure of the H64A myoglobin-nitrosoamphetamine adduct. Nitric Oxide 67:26-29
Sundaresan, Ramya; Parameshwaran, Hari Priya; Yogesha, S D et al. (2017) RNA-Independent DNA Cleavage Activities of Cas9 and Cas12a. Cell Rep 21:3728-3739

Showing the most recent 10 out of 47 publications