The Arkansas Children's Hospital Research Institute (ACHRI) proposes to establish a thematic, multidisciplinary research center titled the Center for Translational Pediatric Research (CTPR). ACHRI is located at Arkansas Children's Hospital, which is the only pediatric hospital in Arkansas; thus, providing a unique environment and clinical population to study pediatric diseases including cancer. Dr. Alan Tackett, a Professor of Pediatrics and an internationally recognized leader in the field of developmental epigenetics, cancer, systems biology and proteomics, will direct the center. He has extensive administrative experience and has mentored multiple junior faculty to the point of receiving their first R01s. NIH has continually funded Dr. Tackett, a native Arkansan, for his entire career, and he has been involved with the NIH IDeA program (through COBRE and INBRE grants) for over a decade. The scientific theme of the CTPR is the study of how pediatric diseases develop from systems biology and mechanistic standpoints with the ultimate goal of identifying intersections of disease and development, which, in turn, will produce targets for therapeutic intervention and the development of new treatments. The thematic focus of the CTPR is unique to COBRE-supported programs nation-wide. The centerpiece of the CTPR will be the use of state-of-the-art systems biology approaches to uncover and mechanistically explore the basis of pediatric diseases. The CTPR will have an Administrative Core, three Research Cores and four Research Projects. The Administrative Core will direct the activities of the center, establish and support Research Cores, oversee a Pilot Project Program and oversee mentoring of Project Leaders through a comprehensive Faculty Development Plan. The CTPR will support Proteomic, Genomic and Systems Biology Bioinformatics Research Cores, which are each essential for the thematic mission of the center. The center will initially invest in four junior faculty members all of whom will utilize systems biology tools to study a variety of pediatric conditions related to brain development, chronic kidney disease, gastrointestinal tract development, bone marrow failure, and cancer. The CTPR will truly be a thematic, multi-disciplinary center bringing together expertise in pediatric research, developmental biology, cancer, imaging, systems biology, bioinformatics, proteomics and genomics. The long-term goal of the CTPR is to provide longevity and sustainability for a thematic, multidisciplinary pediatric research center that utilizes cutting-edge systems biology technologies and state-of-the-art translational research to study pediatric diseases. The short- term goal for Phase I of the CTPR is to follow a Center Organization and Management Plan to establish the foundation of the center, develop and mentor junior investigators with a Faculty Development Plan, and grow the center members to a critical mass necessary to position the group to be competitive for extramural support beyond COBRE-funding.

Public Health Relevance

The Arkansas Children's Hospital Research Institute (ACHRI) will establish a thematic, multidisciplinary research center titled the Center for Translational Pediatric Research (CTPR). Establishment of the CTPR will have a resounding impact on the research infrastructure at ACHRI, one which will ensure that new discoveries and the new knowledge they produce can be translated into novel treatments for children. This COBRE grant will allow researchers at ACHRI to build a world-class, one-of-a-kind center that leverages existing pediatric research at ACHRI and cutting-edge scientific technologies to provide better care to children in Arkansas and across the nation.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
1P20GM121293-01
Application #
9210170
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Gao, Hongwei
Project Start
2017-07-11
Project End
2022-06-30
Budget Start
2017-07-11
Budget End
2018-06-30
Support Year
1
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Arkansas Children's Hospital Research Institute
Department
Type
DUNS #
002593692
City
Little Rock
State
AR
Country
United States
Zip Code
72202
Bolouri, Hamid; Farrar, Jason E; Triche Jr, Timothy et al. (2018) The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions. Nat Med 24:103-112
Zhang, Xin; Zhang, Suping; Liu, Xingui et al. (2018) Oxidation resistance 1 is a novel senolytic target. Aging Cell :e12780
Lo, Dennis; Kennedy, Joshua L; Kurten, Richard C et al. (2018) Modulation of airway hyperresponsiveness by rhinovirus exposure. Respir Res 19:208
Salinas, Eduardo; Gupta, Arundhati; Sifford, Jeffrey M et al. (2018) Conditional mutagenesis in vivo reveals cell type- and infection stage-specific requirements for LANA in chronic MHV68 infection. PLoS Pathog 14:e1006865
Kennedy, Joshua L; Koziol-White, Cynthia J; Jeffus, Susanne et al. (2018) Effects of rhinovirus 39 infection on airway hyperresponsiveness to carbachol in human airways precision cut lung slices. J Allergy Clin Immunol 141:1887-1890.e1
Barham, Caroline; Fil, Daniel; Byrum, Stephanie D et al. (2018) RNA-Seq Analysis of Spinal Cord Tissues from hPFN1G118V Transgenic Mouse Model of ALS at Pre-symptomatic and End-Stages of Disease. Sci Rep 8:13737
Kriss, Crystina L; Gregory-Lott, Emily; Storey, Aaron J et al. (2018) In Vivo Metabolic Tracing Demonstrates the Site-Specific Contribution of Hepatic Ethanol Metabolism to Histone Acetylation. Alcohol Clin Exp Res 42:1909-1923
Dinwiddie, Darrell L; Denson, Jesse L; Kennedy, Joshua L (2018) Role of the Airway Microbiome in Respiratory Infections and Asthma in Children. Pediatr Allergy Immunol Pulmonol 31:236-240
Byrum, Stephanie D; Loughran, Allister J; Beenken, Karen E et al. (2018) Label-Free Proteomic Approach to Characterize Protease-Dependent and -Independent Effects of sarA Inactivation on the Staphylococcus aureus Exoproteome. J Proteome Res 17:3384-3395
Mao, Xiao W; Byrum, Stephanie; Nishiyama, Nina C et al. (2018) Impact of Spaceflight and Artificial Gravity on the Mouse Retina: Biochemical and Proteomic Analysis. Int J Mol Sci 19:

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