EXCEED THE SPACEPROVIDED.This application is to seek continuing support for the RCRII program at the University of Puerto Rico MedicalSciences Campus (UPR-MSC). During two previous funding periods, the RCRII program at UPR-MSC hasestablished itself as a critical an essential component in achieving the institutional goals of advancing ourknowledge of minority health. Compared to our last five-year funding period the RCRII has demonstrated asubstantial increase in clinical research activities, with an increment of 284% in the number of investigators,an increment of 200% in the number of protocols utilizing the RCRII, and an increase of 250% in NIHresearch funds obtained in the institution. Our major goals for this renewal are to contribute to further thedevelopment of clinical research in the broadly defined areas of neuroscience, infectious diseases includingHIV, cancer and respiratory diseases, with particular attention to areas and issues that disproportionatelyaffect minorities. The submitted protocols make full use of the RCRII resources and represent successfulmultidisciplinary collaborations that link basic with clinical science. Our specific objectives are to increase thenumber and quality of the investigator-initiated studies performed at the RCRII and contribute to a substantialincrease in the number of publications, while at the same time make important contributions to theknowledge and understanding of those problems that are relevant to our population. To achieve those goalsand to serve better the necessities of the UPR-MSC investigators, for this renewal we have reorganized thecore laboratory, we have developed an expanded informatics core, we have strengthened our biostatisticscore and we will be providing added support in scientific writing. The UPR-Medical Sciences Campus is wellpositioned to undertake these ambitious goals given its access to minorities, the increment in recentlyestablished resources and programs focused in the area of clinical research, and a leadership that is fullycommitted to the success of the RCRII program. Support of the Clinical Research Program at the MedicalSciences Campus and those under development, will be the core mechanism for attainment of the majorongoing goals specified above.
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