EXCEED THE SPACEPROVIDED.Core A of the COBRE grant, the administrative and mentoring core, will provide (1) administrative leadershipand coordination of the overall research effort, (2) offer expert external review, mentoring, and consultation forthe optimal progress of the scientific research effort and the professional development of the mentees, (3)enhance communication of research results by organizing meetings, workshops, and symposia related tocancer research, and data sharing, and provide appropriate accounting and other management support.The major responsibilities of Core A will involve the administration of five COBRE projects, replacement ofCOBRE projects, First Awards selection, and start-up enhancement package selection. This process willinvolve external peer-review. Core A will also oversee three scientific cores, (1) High Throughput Screening(Core B), (2) Medicinal Chemistry (Core C), and (3) the Transgenic Animal and Knock-out Mouse (TAKOM)laboratory (Core D).Experienced faculty, the Internal Advisory Board (IAB), and the External Advisory Board (EAB) will mentorthe COBRE faculty. Mentoring will also take place through participation and organization of workshops,symposia, and seminars, including grant-writing workshops.Core A will also manage the monthly COBRE meetings, the IAB and EAB meetings, the NIH-data sharingplan, prepare the annual progress report, manage a COBRE website, and keep the COBRE brochureupdated. Core A is also responsible for accounting management.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR015563-09
Application #
7417599
Study Section
Special Emphasis Panel (ZRR1-RI-8 (01))
Program Officer
Sayre, Michael
Project Start
2000-09-30
Project End
2010-02-28
Budget Start
2008-03-01
Budget End
2009-02-28
Support Year
9
Fiscal Year
2008
Total Cost
$1,931,306
Indirect Cost
Name
University of Kansas Lawrence
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
076248616
City
Lawrence
State
KS
Country
United States
Zip Code
66045
Subramanian, Chitra; Grogan, Patrick T; Opipari, Valerie P et al. (2018) Novel natural withanolides induce apoptosis and inhibit migration of neuroblastoma cells through down regulation of N-myc and suppression of Akt/mTOR/NF-?B activation. Oncotarget 9:14509-14523
Ishiguro, Susumu; Kawabata, Atsushi; Zulbaran-Rojas, Alejandro et al. (2018) Co-treatment with a C1B5 peptide of protein kinase C? and a low dose of gemcitabine strongly attenuated pancreatic cancer growth in mice through T cell activation. Biochem Biophys Res Commun 495:962-968
He, Chenchen; Duan, Shaofeng; Dong, Liang et al. (2017) Characterization of a novel p110?-specific inhibitor BL140 that overcomes MDV3100-resistance in castration-resistant prostate cancer cells. Prostate 77:1187-1198
White, Peter T; Subramanian, Chitra; Zhu, Qing et al. (2016) Novel HSP90 inhibitors effectively target functions of thyroid cancer stem cell preventing migration and invasion. Surgery 159:142-51
Ohta, Naomi; Ishiguro, Susumu; Kawabata, Atsushi et al. (2015) Human umbilical cord matrix mesenchymal stem cells suppress the growth of breast cancer by expression of tumor suppressor genes. PLoS One 10:e0123756
Li, Benyi; Thrasher, James Brantley; Terranova, Paul (2015) Glycogen synthase kinase-3: a potential preventive target for prostate cancer management. Urol Oncol 33:456-63
Ishiguro, Susumu; Yoshimura, Kiyoshi; Tsunedomi, Ryouichi et al. (2015) Involvement of angiotensin II type 2 receptor (AT2R) signaling in human pancreatic ductal adenocarcinoma (PDAC): a novel AT2R agonist effectively attenuates growth of PDAC grafts in mice. Cancer Biol Ther 16:307-16
Li, Benyi; Sun, Aijing; Jiang, Wencong et al. (2014) PI-3 kinase p110?: a therapeutic target in advanced prostate cancers. Am J Clin Exp Urol 2:188-98
Bibis, Stergios S; Dahlstrom, Kelly; Zhu, Tongtong et al. (2014) Characterization of Leishmania major phosphatidylethanolamine methyltransferases LmjPEM1 and LmjPEM2 and their inhibition by choline analogs. Mol Biochem Parasitol 196:90-9
Subramanian, Chitra; Zhang, Huaping; Gallagher, Robert et al. (2014) Withanolides are potent novel targeted therapeutic agents against adrenocortical carcinomas. World J Surg 38:1343-52

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