The long range goal of this project is to establish a Center of Biomedical Research Excellence that serves two primary function: i) to advance our understanding of Structural and Functional Neuroscience and ii) to increase the number of NIH-RO1-funded investigators in Montana. We propose to create a Center for Structural and Functional Neuroscience at the University of Montana using a well balanced combination of new faculty recruitment, development of needed instrumentation, and sub- project support for talented young faculty already in place. Research in the proposed Center will emphasize CNS protein structure and function as related to signal transduction, development and neurodegeneration. This thematic focus, not only builds on existing faculty strengths, but also represents a field in which interdisciplinary research at a growing University (without a medical school) can make a significant contribution to one of the highest priority health care issues facing our nation: understanding and lessening the burden of neurological diseases. The proposed Center will be developed using the following specific aims:
Aim I - Enhance the critical mas of competitive neuroscientists at the University of Montana through strategic recruitment of three new faculty.
Aim II - Promote the development of competitive neuroscience faculty through the support of individual subprojects Aim III - Enhance the infrastructure for neuroscience research through the acquisition of critically needed instrumentation for a shared core spectroscopy lab for studies of CNS protein structure and function.
Aim I V - Establish a support network for Center neuroscientists that promotes infrastructure development, collaborative interaction and, most importantly, mentoring.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Exploratory Grants (P20)
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Special Emphasis Panel (ZRR1-RCMI-2 (02))
Program Officer
Gorospe, Rafael
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University of Montana
Other Health Professions
Schools of Pharmacy
United States
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Gates, Christina; Backos, Donald S; Reigan, Philip et al. (2018) Isoxazolo[3,4-d]pyridazinones positively modulate the metabotropic glutamate subtypes 2 and 4. Bioorg Med Chem 26:4797-4803
Bayat Mokhtari, Elham; Lawrence, J Josh; Stone, Emily F (2018) Data Driven Models of Short-Term Synaptic Plasticity. Front Comput Neurosci 12:32
Gupta, Tarun; Morgan, Hannah R; Andrews, Jonathan C et al. (2017) Methyl-CpG binding domain proteins inhibit interspecies courtship and promote aggression in Drosophila. Sci Rep 7:5420
Steiger, Scott A; Li, Chun; Backos, Donald S et al. (2017) Dimeric isoxazolyl-1,4-dihydropyridines have enhanced binding at the multi-drug resistance transporter. Bioorg Med Chem 25:3223-3234
Stine, Jessica M; Ahl, Gabriel J H; Schlenker, Casey et al. (2017) The Interaction between the Third Type III Domain from Fibronectin and Anastellin Involves ?-Strand Exchange. Biochemistry 56:4667-4675
Park, Sunyoung; Nevin, Andrew B C; Cardozo-Pelaez, Fernando et al. (2016) Pb exposure prolongs the time period for postnatal transient uptake of 5-HT by murine LSO neurons. Neurotoxicology 57:258-269
Gábriel, Robert; Erdélyi, Ferenc; Szabó, Gábor et al. (2016) Ectopic transgene expression in the retina of four transgenic mouse lines. Brain Struct Funct 221:3729-41
Gupta, T; Morgan, H R; Bailey, J A et al. (2016) Functional conservation of MBD proteins: MeCP2 and Drosophila MBD proteins alter sleep. Genes Brain Behav 15:757-774
Steiger, Scott A; Li, Chun; Campana, Charles F et al. (2016) Lanthanide and asymmetric catalyzed syntheses of sterically hindered 4-isoxazolyl-1,4-dihydropyridines and 4-isoxazolyl-quinolones. Tetrahedron Lett 57:423-425
Yasuda, Nobuo; Bolin, Celeste; Cardozo-Pelaez, Fernando et al. (2015) Effects of repeated bouts of long-duration endurance exercise on muscle and urinary levels of 8-hydroxy-2'-deoxyguanosine in moderately trained cyclists. J Sports Sci 33:1692-701

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