Abstract

The overall goal of Dr. Ikonomidis project is to employ a transgenic approach (made possible through Core B) with an integrated systems physiological approach to identify candidate molecular signals and cellular events that contribute to the progression of remodeling. He will use remodeling models of myocardial infarct or aortic aneurysm created by surgical induction. Subsequently, he will use transgenic approaches involving metalloproteinases or the transcription factors that regulate them to create animal models of aortic aneurysm.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
1P20RR016434-01
Application #
6553788
Study Section
Special Emphasis Panel (ZRR1)
Project Start
2001-09-30
Project End
2006-08-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
Medical University of South Carolina
Department
Type
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425

  Publications

Soiberman, Uri; Foster, James W; Jun, Albert S et al. (2017) Pathophysiology of Keratoconus: What Do We Know Today. Open Ophthalmol J 11:252-261
Karousou, Evgenia; Misra, Suniti; Ghatak, Shibnath et al. (2017) Roles and targeting of the HAS/hyaluronan/CD44 molecular system in cancer. Matrix Biol 59:3-22
Moreno-Rodriguez, Ricardo A; Krug, Edward L; Reyes, Leticia et al. (2017) Linear array of multi-substrate tracts for simultaneous assessment of cell adhesion, migration, and differentiation. Biotechniques 63:267-274
Liu, Gang; Cooley, Marion A; Jarnicki, Andrew G et al. (2016) Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases. JCI Insight 1:
Menon, Vinal; Junor, Lorain; Balhaj, Marwa et al. (2016) A Novel Ex Ovo Banding Technique to Alter Intracardiac Hemodynamics in an Embryonic Chicken System. J Vis Exp :
Dupuis, Loren E; Doucette, Lorna; Rice, A Kittrell et al. (2016) Development of myotendinous-like junctions that anchor cardiac valves requires fibromodulin and lumican. Dev Dyn 245:1029-42
Olsen, T R; Mattix, B; Casco, M et al. (2015) Manipulation of cellular spheroid composition and the effects on vascular tissue fusion. Acta Biomater 13:188-98
Stevens, Shawn M; Brown, LaShardai N; Ezell, Paula C et al. (2015) The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration. J Vis Exp :
Menon, Vinal; Eberth, John F; Goodwin, Richard L et al. (2015) Altered Hemodynamics in the Embryonic Heart Affects Outflow Valve Development. J Cardiovasc Dev Dis 2:108-124
Dupuis, Loren E; Berger, Matthew G; Feldman, Samuel et al. (2015) Lumican deficiency results in cardiomyocyte hypertrophy with altered collagen assembly. J Mol Cell Cardiol 84:70-80

Showing the most recent 10 out of 154 publications