This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Diverse extracellular stimuli, ranging from G protein-coupled receptor (GPCR) ligands to cytokines and reactive oxygen species, regulate the proliferation of vascular smooth muscle in vitro and contribute to the development of vascular disease in vivo. A common cellular response to each of these stimuli is the proteolytic generation of peptide growth factors that induce the 'transactivation' of the ErbB family of growth factor receptors. With four known ErbB receptors and ten known ligands, the ErbB system provides a complex network for the control of cellular proliferation, survival, cell migration and apoptosis. This project will determine how transactivated ErbB receptors contribute to vascular smooth muscle cell (VSMC) responses to diverse stimuli and test whether transactivation constitutes a final common pathway for growth regulation in vascular tissue. Understanding how multiple signals regulate ErbB receptor function may provide a rational basis for the treatment or prevention of vascular disease characterized by the pathophysiologic hyperplasia of vascular smooth muscle.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Exploratory Grants (P20)
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Special Emphasis Panel (ZRR1-RI-8 (01))
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Medical University of South Carolina
Anatomy/Cell Biology
Schools of Medicine
United States
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Soiberman, Uri; Foster, James W; Jun, Albert S et al. (2017) Pathophysiology of Keratoconus: What Do We Know Today. Open Ophthalmol J 11:252-261
Karousou, Evgenia; Misra, Suniti; Ghatak, Shibnath et al. (2017) Roles and targeting of the HAS/hyaluronan/CD44 molecular system in cancer. Matrix Biol 59:3-22
Moreno-Rodriguez, Ricardo A; Krug, Edward L; Reyes, Leticia et al. (2017) Linear array of multi-substrate tracts for simultaneous assessment of cell adhesion, migration, and differentiation. Biotechniques 63:267-274
Liu, Gang; Cooley, Marion A; Jarnicki, Andrew G et al. (2016) Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases. JCI Insight 1:
Menon, Vinal; Junor, Lorain; Balhaj, Marwa et al. (2016) A Novel Ex Ovo Banding Technique to Alter Intracardiac Hemodynamics in an Embryonic Chicken System. J Vis Exp :
Dupuis, Loren E; Doucette, Lorna; Rice, A Kittrell et al. (2016) Development of myotendinous-like junctions that anchor cardiac valves requires fibromodulin and lumican. Dev Dyn 245:1029-42
Olsen, T R; Mattix, B; Casco, M et al. (2015) Manipulation of cellular spheroid composition and the effects on vascular tissue fusion. Acta Biomater 13:188-98
Stevens, Shawn M; Brown, LaShardai N; Ezell, Paula C et al. (2015) The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration. J Vis Exp :
Menon, Vinal; Eberth, John F; Goodwin, Richard L et al. (2015) Altered Hemodynamics in the Embryonic Heart Affects Outflow Valve Development. J Cardiovasc Dev Dis 2:108-124
Dupuis, Loren E; Berger, Matthew G; Feldman, Samuel et al. (2015) Lumican deficiency results in cardiomyocyte hypertrophy with altered collagen assembly. J Mol Cell Cardiol 84:70-80

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