This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Diverse extracellular stimuli, ranging from G protein-coupled receptor (GPCR) ligands to cytokines and reactive oxygen species, regulate the proliferation of vascular smooth muscle in vitro and contribute to the development of vascular disease in vivo. A common cellular response to each of these stimuli is the proteolytic generation of peptide growth factors that induce the 'transactivation' of the ErbB family of growth factor receptors. With four known ErbB receptors and ten known ligands, the ErbB system provides a complex network for the control of cellular proliferation, survival, cell migration and apoptosis. This project will determine how transactivated ErbB receptors contribute to vascular smooth muscle cell (VSMC) responses to diverse stimuli and test whether transactivation constitutes a final common pathway for growth regulation in vascular tissue. Understanding how multiple signals regulate ErbB receptor function may provide a rational basis for the treatment or prevention of vascular disease characterized by the pathophysiologic hyperplasia of vascular smooth muscle.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
2P20RR016434-06
Application #
7381241
Study Section
Special Emphasis Panel (ZRR1-RI-8 (01))
Project Start
2006-07-01
Project End
2007-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
6
Fiscal Year
2006
Total Cost
$47,787
Indirect Cost
Name
Medical University of South Carolina
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
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