This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The Informatics Core is an administrative Core that provides support to COBRE members for the use of existing proteomics (Proteomics Facility Core) and genomics (Microarray Shared Resource) facilities at Dartmouth. We propose that by incentivizing the use of these Cores, it will provide valuable new technologies to the young COBRE investigators that may not have access to the technology due to limited budgets, as well as introduce to established investigators, new technologies to which they are not familiar. Extended, shared use of these Cores will create a sense of community and common language for scientists to interact between ongoing COBRE programs and the scientific community, as a whole. Within the Proteomics Core investigators will find support for the: 1. Isolation and purification of proteins, 2. 2D Gel Analysis of Macromolecules. 3. Mass Spectral Analysis of Macromolecules. 4. Quantitative Analysis of Biomolecular Interactions, 5. Bioinformatics Support Services. Within the MicroArray Shared Resource, COBRE members will find support for the: 1. Analysis of Gene Expression by QT-RT PCR, 2. Full-Genome transcriptional profiling of both of mouse and human genes and 3. Bioinformatics support. Resources provided to this Core will underwrite the cost of service, on a sliding scale, for present COBRE members, past COBRE members and members of other COBRE initiatives within the Dartmouth community. In addition to providing additional access to these Cores to COBRE members, we think that this initiative will strengthen and extend existing inter-COBRE interactions.
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