Abstract

This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The progression of knee osteoarthritis (OA) results in deterioration of articular cartilage and may ultimately necessitate surgical intervention to alleviate joint pain and enable normal performance of activities of daily living. Adaptations to muscle coordination patterns occur presumably in response to pain and gait deviations become more pronounced as the diseases progresses. The proposed study is designed to investigate the evolution of muscle coordination patterns during the progression of OA, to relate changes in coordination patterns to changes in gait, and to determine whether these changes effectively reduce loads at the knee.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
2P20RR016458-06A1
Application #
7609994
Study Section
Special Emphasis Panel (ZRR1-RI-5 (01))
Project Start
2007-06-01
Project End
2008-05-31
Budget Start
2007-06-01
Budget End
2008-05-31
Support Year
6
Fiscal Year
2007
Total Cost
$166,630
Indirect Cost

  Institution

Name
University of Delaware
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
059007500
City
Newark
State
DE
Country
United States
Zip Code
19716

  Publications

Wellsandt, Elizabeth; Khandha, Ashutosh; Manal, Kurt et al. (2017) Predictors of knee joint loading after anterior cruciate ligament reconstruction. J Orthop Res 35:651-656
Pozzi, Federico; Marmon, Adam R; Snyder-Mackler, Lynn et al. (2016) Lower leg compensatory strategies during performance of a step up and over task in patient six-months after total knee arthroplasty. Gait Posture 49:41-46
Moore, A C; DeLucca, J F; Elliott, D M et al. (2016) Quantifying Cartilage Contact Modulus, Tension Modulus, and Permeability With Hertzian Biphasic Creep. J Tribol 138:0414051-414057
Rehmann, Matthew S; Luna, Jesus I; Maverakis, Emanual et al. (2016) Tuning microenvironment modulus and biochemical composition promotes human mesenchymal stem cell tenogenic differentiation. J Biomed Mater Res A 104:1162-74
Abujaber, Sumayeh; Gillispie, Gregory; Marmon, Adam et al. (2015) Validity of the Nintendo Wii Balance Board to assess weight bearing asymmetry during sit-to-stand and return-to-sit task. Gait Posture 41:676-82
Zimmerman, B K; Bonnevie, E D; Park, M et al. (2015) Role of interstitial fluid pressurization in TMJ lubrication. J Dent Res 94:85-92
Moore, A C; Zimmerman, B K; Chen, X et al. (2015) Experimental characterization of biphasic materials using rate-controlled Hertzian indentation. Tribol Int 89:2-8
Moore, A C; Burris, D L (2015) Tribological and material properties for cartilage of and throughout the bovine stifle: support for the altered joint kinematics hypothesis of osteoarthritis. Osteoarthritis Cartilage 23:161-9
Pozzi, Federico; Snyder-Mackler, Lynn; Zeni Jr, Joseph (2015) Relationship between biomechanical asymmetries during a step up and over task and stair climbing after total knee arthroplasty. Clin Biomech (Bristol, Avon) 30:78-85
Wang, Bin; Lai, Xiaohan; Price, Christopher et al. (2014) Perlecan-containing pericellular matrix regulates solute transport and mechanosensing within the osteocyte lacunar-canalicular system. J Bone Miner Res 29:878-91

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