This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Nucleotide excision repair (NER) and transcription deficiencies contribute to several human diseases and conditions, such as cancer, neurological disorders and aging. Our long-term goal is to define the NER and transcription mechanisms responsible for human disease and to identify molecular targets for the rational design of novel therapeutic agents. The human MMS19 gene has been recently cloned and shown to be required for effective NER and Pol II transcription. The proposed studies will determine the precise role of human MMS19 spliced variants in NER and transcription, and map the MMS19 domains required for NER and Pol II transcription. We have identified three novel proteins which, in a yeast two-hybrid system, interact specifically with MMS19 C-terminal domain. We will evaluate these protein interactions in mammalian cells and determine whether these proteins have a role in NER and/or Pol II transcription. A direct link between MMS19 and human disease has not as yet been established. Nonetheless, these studies should reveal the role of various proteins in the NER and transcription processes, and they might provide important insights into the mechanisms of several human diseases and conditions.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016478-07
Application #
7610261
Study Section
Special Emphasis Panel (ZRR1-RI-7 (02))
Project Start
2007-05-01
Project End
2008-04-30
Budget Start
2007-05-01
Budget End
2008-04-30
Support Year
7
Fiscal Year
2007
Total Cost
$73,476
Indirect Cost
Name
University of Oklahoma Health Sciences Center
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
878648294
City
Oklahoma City
State
OK
Country
United States
Zip Code
73117
Hu, Zihua; Jiang, Kaiyu; Frank, Mark Barton et al. (2018) Modeling Transcriptional Rewiring in Neutrophils Through the Course of Treated Juvenile Idiopathic Arthritis. Sci Rep 8:7805
Wetherill, Marianna S; Williams, Mary B; Gray, Karen A (2017) SNAP-Based Incentive Programs at Farmers' Markets: Adaptation Considerations for Temporary Assistance for Needy Families (TANF) Recipients. J Nutr Educ Behav 49:743-751.e1
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Hu, Zihua; Jiang, Kaiyu; Frank, Mark Barton et al. (2016) Complexity and Specificity of the Neutrophil Transcriptomes in Juvenile Idiopathic Arthritis. Sci Rep 6:27453
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Shircliff, Anthony D; Wilson, Kevin R; Cannon, Desiray J et al. (2015) Synthesis, structural studies, and oxidation catalysis of the manganese(II), iron(II), and copper(II) complexes of a 2-pyridylmethyl pendant armed side-bridged cyclam. Inorg Chem Commun 59:71-75
Seong, Jaehoon; Jeong, Woowon; Smith, Nataliya et al. (2015) Hemodynamic effects of long-term morphological changes in the human carotid sinus. J Biomech 48:956-62

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