This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity is associate with hypertension, type 2 diabetes, high blood lipid levels, cardiovascular disease and kidney failure. The primary focus of the research is the pathogenesis of obesity-linked kidney disease using a genetic model of obesity, the obese Zucker rat. Studies are aimed at examining the early molecular events leading to the development of kidney failure and examining new treatments, both dietary and pharmacologic, to prevent and possibly reverse obesity-linked kidney disease.
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