The LSU-HSC leads a partnership of four Louisiana institutions in a COBRE on neuroscience research. The Program Director and established scientists are mentors to selected, highly promising junior faculty who propose four research projects that have been designed for the common goal of mentoring to build new nationally competitive research. The scientific focus is on a central issue of neurobiology: to understand the cellular and molecular basis of synaptic plasticity and neuronal survival critical to clarify the pathophysiology of neurological disorders such as: stroke, neural trauma and neurodegenerative diseases. This multidisciplinary program involves cellular neurophysiology, molecular biology and behavioral neuroscience. To support the COBRE projects, core resources include facilities for imaging , neurochemistry of lipid messengers and molecular neurobiology. A recruitment plan for years 2 to 5 further benefits the collaborating institutions by actively attracting new research faculty who will work under the guidance of established neuroscientists as mentors. A relatively small administrative core funding is requested.
The specific aims to attain these objectives are: 1) to promote faculty development through research projects; 2) to further develop a critical mass of competitive extramurally funded investigators by the recruitment, start up, mentoring and retention of new faculty members; 3) to enhance the infrastructure critical for expanding neuroscience capability in Louisiana by developing three core research modules at LSUHSC; 4) to provide scientific and grantsmanship mentoring and strengthen the support network that promotes interactions; and 5) to implement interim and outcome evaluations so as to keep this COBRE program on track. This partnership rests on existing expertise and in our firm decision to build a scientifically successful neuroscience alliance in Louisiana. The four target faculty and the four to-be-recruited faculty are the critical building blocks to achieve these goals. The core resources are vital to the overall success of this consortium, not only in neuroscience but in all the biomedical sciences. The plans for mentoring junior faculty and the recruitment plan will ensure a steady stream of new nationally competitive neuroscientists in Louisiana.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-A (01))
Program Officer
Liu, Yanping
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Louisiana State University Hsc New Orleans
Schools of Medicine
New Orleans
United States
Zip Code
Ponnath, Abhilash; Farris, Hamilton E (2014) Sound-by-sound thalamic stimulation modulates midbrain auditory excitability and relative binaural sensitivity in frogs. Front Neural Circuits 8:85
Ferland, Chantelle L; Harris, Erin P; Lam, Mai et al. (2014) Facilitation of the HPA axis to a novel acute stress following chronic stress exposure modulates histone acetylation and the ERK/MAPK pathway in the dentate gyrus of male rats. Endocrinology 155:2942-52
Lentz, Jennifer J; Jodelka, Francine M; Hinrich, Anthony J et al. (2013) Rescue of hearing and vestibular function by antisense oligonucleotides in a mouse model of human deafness. Nat Med 19:345-50
Renner, Nicole A; Sansing, Hope A; Inglis, Fiona M et al. (2013) Transient acidification and subsequent proinflammatory cytokine stimulation of astrocytes induce distinct activation phenotypes. J Cell Physiol 228:1284-94
Harrison, L M; Muller, S H; Spano, D (2013) Effects of the Ras homolog Rhes on Akt/protein kinase B and glycogen synthase kinase 3 phosphorylation in striatum. Neuroscience 236:21-30
Ferland, Chantelle L; Hawley, Wayne R; Puckett, Rosemary E et al. (2013) Sirtuin activity in dentate gyrus contributes to chronic stress-induced behavior and extracellular signal-regulated protein kinases 1 and 2 cascade changes in the hippocampus. Biol Psychiatry 74:927-35
Ponnath, Abhilash; Hoke, Kim L; Farris, Hamilton E (2013) Stimulus change detection in phasic auditory units in the frog midbrain: frequency and ear specific adaptation. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 199:295-313
Imaizumi, Kazuo; Shih, Jonathan Y; Farris, Hamilton E (2013) Global hyper-synchronous spontaneous activity in the developing optic tectum. Sci Rep 3:1552
Jones, Patricia L; Farris, Hamilton E; Ryan, Michael J et al. (2013) Do frog-eating bats perceptually bind the complex components of frog calls? J Comp Physiol A Neuroethol Sens Neural Behav Physiol 199:279-83
Harrison, Laura M (2012) Rhes: a GTP-binding protein integral to striatal physiology and pathology. Cell Mol Neurobiol 32:907-18

Showing the most recent 10 out of 101 publications