Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator.
The aims are as follows: 1) K3/DR/C regulates dentate granule cell synaptic plasticity at the perforant path/dentate granule cell synapse. 2) Determine whether release of Ca2+ from intracellular stores is sufficient and Ca2+ binding to EF hands is necessary to cause nuclear translocation of K3/DR/C in neurons. 3) Determine whether direct phosphorylation of K3/DR/C by kinases modulates DNA binding properties and gene transcription.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016816-09
Application #
8167396
Study Section
Special Emphasis Panel (ZRR1-RI-8 (01))
Project Start
2010-02-01
Project End
2011-01-31
Budget Start
2010-02-01
Budget End
2011-01-31
Support Year
9
Fiscal Year
2010
Total Cost
$159,748
Indirect Cost

  Institution

Name
Louisiana State Univ Hsc New Orleans
Department
Neurology
Type
Schools of Medicine
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112

  Publications

Ponnath, Abhilash; Farris, Hamilton E (2014) Sound-by-sound thalamic stimulation modulates midbrain auditory excitability and relative binaural sensitivity in frogs. Front Neural Circuits 8:85
Ferland, Chantelle L; Harris, Erin P; Lam, Mai et al. (2014) Facilitation of the HPA axis to a novel acute stress following chronic stress exposure modulates histone acetylation and the ERK/MAPK pathway in the dentate gyrus of male rats. Endocrinology 155:2942-52
Lentz, Jennifer J; Jodelka, Francine M; Hinrich, Anthony J et al. (2013) Rescue of hearing and vestibular function by antisense oligonucleotides in a mouse model of human deafness. Nat Med 19:345-50
Renner, Nicole A; Sansing, Hope A; Inglis, Fiona M et al. (2013) Transient acidification and subsequent proinflammatory cytokine stimulation of astrocytes induce distinct activation phenotypes. J Cell Physiol 228:1284-94
Harrison, L M; Muller, S H; Spano, D (2013) Effects of the Ras homolog Rhes on Akt/protein kinase B and glycogen synthase kinase 3 phosphorylation in striatum. Neuroscience 236:21-30
Ferland, Chantelle L; Hawley, Wayne R; Puckett, Rosemary E et al. (2013) Sirtuin activity in dentate gyrus contributes to chronic stress-induced behavior and extracellular signal-regulated protein kinases 1 and 2 cascade changes in the hippocampus. Biol Psychiatry 74:927-35
Ponnath, Abhilash; Hoke, Kim L; Farris, Hamilton E (2013) Stimulus change detection in phasic auditory units in the frog midbrain: frequency and ear specific adaptation. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 199:295-313
Imaizumi, Kazuo; Shih, Jonathan Y; Farris, Hamilton E (2013) Global hyper-synchronous spontaneous activity in the developing optic tectum. Sci Rep 3:1552
Jones, Patricia L; Farris, Hamilton E; Ryan, Michael J et al. (2013) Do frog-eating bats perceptually bind the complex components of frog calls? J Comp Physiol A Neuroethol Sens Neural Behav Physiol 199:279-83
Harrison, Laura M (2012) Rhes: a GTP-binding protein integral to striatal physiology and pathology. Cell Mol Neurobiol 32:907-18

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