Building on the critical mass of expertise and infrastructure assembled during our first funding period, this proposal seeks five more years of support through NCRR's COBRE program to enable us to further strengthen and consolidate a self-sustaining and flourishing Center for Evolutionary and Theoretical Immunology (CETI). Once again, both junior and senior faculty scholars from the Biology and Computer Science Departments at the University of New Mexico and the Los Alamos National Labs will undertake research projects that seek to reveal basic design principles of immune systems, that model the interactions between pathogens and immune systems, and that explore the evolution of immune responses across animal phyla. Consequently, we will better understand how invertebrate vectors transmit infectious diseases, how pathogens defend themselves from immune attack and how the comparative study of immune systems can lead to exciting new conceptual frameworks and paradigms. We will also improve our mentoring program to develop independently-funded junior investigators, provide our members logistical support in grant preparation and management and at every opportunity strive to improve their long-term career prospects. We will hire additional CETI-related tenure track faculty and continue to partner with other NCRR programs and the UNM administration to support and improve CETI's core facilities in molecular biology, controlled environments and mass spectrometry/proteomics. We will also expand and improve the physical home of CETI by moving into new facilities that CETI has leveraged through productive partnerships with the UNM administration, and we will initiate a new seed grant program to increase the breadth and impact of CETI. We will develop multi-investigator proposals to mark CETI's graduation from NCRR funding and continue to seek new ways to promote integration and collaborations among our members and with the New Mexico research community. Lastly, CETI will increasingly serve as a catalyst to develop new training and biomedical research opportunities in our state and will use our critical mass to undertake initiatives and favor research enabling us to achieve world class recognition and prominence.

Public Health Relevance

(provided by applicant): Research conducted by investigators at the Center for Evolutionary and Theoretical Immunology will increase our understanding of the transmission of human parasitic diseases and may lead to the development of new therapeutics. In addition, models of viral diseases will be developed that will improve our ability to predict the spread of epidemics as well as evaluate effectiveness of different treatment regimes.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR018754-08
Application #
8092809
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Program Officer
Liu, Yanping
Project Start
2003-09-30
Project End
2014-05-31
Budget Start
2011-06-01
Budget End
2012-05-31
Support Year
8
Fiscal Year
2011
Total Cost
$2,238,776
Indirect Cost
Name
University of New Mexico
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
868853094
City
Albuquerque
State
NM
Country
United States
Zip Code
87131
Swanteson-Franz, Rachel J; Marquez, Destinie A; Goldstein, Craig I et al. (2018) New hairworm (Nematomorpha, Gordiida) species described from the Arizona Madrean Sky Islands. Zookeys :131-145
Banerjee, Soumya; Perelson, Alan S; Moses, Melanie (2017) Modelling the effects of phylogeny and body size on within-host pathogen replication and immune response. J R Soc Interface 14:
Gunning, Christian E; Ferrari, Matthew J; Erhardt, Erik B et al. (2017) Evidence of cryptic incidence in childhood diseases. Proc Biol Sci 284:
Brant, Sara V; Loker, Eric S; Casalins, Laura et al. (2017) Phylogenetic Placement of a Schistosome from an Unusual Marine Snail Host, the False Limpet (Siphonaria lessoni) and Gulls (Larus dominicanus) from Argentina with a Brief Review of Marine Schistosomes from Snails. J Parasitol 103:75-82
Hanson, David T; Stutz, Samantha S; Boyer, John S (2016) Why small fluxes matter: the case and approaches for improving measurements of photosynthesis and (photo)respiration. J Exp Bot 67:3027-39
Zhou, Peng; Tachedjian, Mary; Wynne, James W et al. (2016) Contraction of the type I IFN locus and unusual constitutive expression of IFN-? in bats. Proc Natl Acad Sci U S A 113:2696-701
Ernst, Crystal M; Hanelt, Ben; Buddle, Christopher M (2016) Parasitism of Ground Beetles (Coleoptera: Carabidae) by a New Species of Hairworm (Nematomorpha: Gordiida) in Arctic Canada. J Parasitol 102:327-35
Peña, Janeth J; Adema, Coen M (2016) The Planorbid Snail Biomphalaria glabrata Expresses a Hemocyanin-Like Sequence in the Albumen Gland. PLoS One 11:e0168665
Ng, Justin H J; Tachedjian, Mary; Deakin, Janine et al. (2016) Evolution and comparative analysis of the bat MHC-I region. Sci Rep 6:21256
Banerjee, Soumya; Guedj, Jeremie; Ribeiro, Ruy M et al. (2016) Estimating biologically relevant parameters under uncertainty for experimental within-host murine West Nile virus infection. J R Soc Interface 13:

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