Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator.
Specific Aim 1 : To determine the capacity of selected oral microorganisms to activate HIV-1 in latently infected T lymphocytes and macrophages.
Specific Aim 2 : To determine the ability of selected oral microorganisms to elicit mediators from resident cell populations that can activate HIV-1 in latently infected T lymphocytes and macrophages.
Specific Aim 3 : To determine the target receptors for bacterial and host stimulation of the HIV promoter and HIV reactivation in latently infected T cells and macrophages.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
2P20RR020145-06
Application #
7960552
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Project Start
2009-09-30
Project End
2010-07-30
Budget Start
2009-09-30
Budget End
2010-07-30
Support Year
6
Fiscal Year
2009
Total Cost
$186,188
Indirect Cost

  Institution

Name
University of Kentucky
Department
Dentistry
Type
Schools of Dentistry
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506

  Publications

Gonzalez, O A; Kirakodu, S; Novak, M J et al. (2018) Comparative analysis of microbial sensing molecules in mucosal tissues with aging. Immunobiology 223:279-287
Ebersole, J L; Dawson 3rd, D A; Emecen Huja, P et al. (2018) Age and Periodontal Health - Immunological View. Curr Oral Health Rep 5:229-241
Danaher, Robert J; Zhang, Liping; Donley, Connor J et al. (2018) Histone deacetylase inhibitors prevent persistent hypersensitivity in an orofacial neuropathic pain model. Mol Pain 14:1744806918796763
Ebersole, Jeffrey L; Orraca, Luis; Kensler, Terry B et al. (2018) Periodontal disease susceptible matrilines in the Cayo Santiago Macaca mulatta macaques. J Periodontal Res :
Ebersole, J L; Kirakodu, S; Novak, M J et al. (2018) Comparative analysis of expression of microbial sensing molecules in mucosal tissues with periodontal disease. Immunobiology :
Ebersole, Jeffrey L; Al-Sabbagh, Mohanad; Gonzalez, Octavio A et al. (2018) Ageing effects on humoral immune responses in chronic periodontitis. J Clin Periodontol 45:680-692
Lyons, Danielle N; Zhang, Liping; Pandya, Jignesh D et al. (2018) Combination Drug Therapy of Pioglitazone and D-cycloserine Attenuates Chronic Orofacial Neuropathic Pain and Anxiety by Improving Mitochondrial Function Following Trigeminal Nerve Injury. Clin J Pain 34:168-177
Lyons, Danielle N; Zhang, Liping; Danaher, Robert J et al. (2017) PPAR? Agonists Attenuate Trigeminal Neuropathic Pain. Clin J Pain 33:1071-1080
Nagarajan, R; Miller, C S; Dawson 3rd, D et al. (2017) Cross-talk between clinical and host-response parameters of periodontitis in smokers. J Periodontal Res 52:342-352
Ebersole, J L; Kryscio, R J; Campbell, C et al. (2017) Salivary and serum adiponectin and C-reactive protein levels in acute myocardial infarction related to body mass index and oral health. J Periodontal Res 52:419-427

Showing the most recent 10 out of 83 publications