This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The Microarray core facility utilizes the Affymetrix GeneChip 2500 system that includes Hybridization Station 640, Fluidics Station 400 and Scanner 2500. An Agilant bioanalyzer 2100 is also available for RNA analysis. GeneChip expression analysis probe arrays are purchased from Affymetrix. The microarray core is also equipped with a variety of tools for data analysis, networking and database management. Data are analyzed using the Microarray Suite, DMT, Micro DB, GeneSpring and Gene Sifter software packages. The Microarray Core provides RNA expression-profiling services including quality testing of RNA, hybridization to GeneChip probe arrays, image processing, primary data analysis, data delivery, and access to Biomformatics tools, which are managed by the Bioinformatics Core. User support is available for target preparation and data analysis using various software packages. The Bioinformatics core facility provides support with a Unix system administratorand two programmers.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Exploratory Grants (P20)
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Special Emphasis Panel (ZRR1-RI-8 (01))
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University of Vermont & St Agric College
Internal Medicine/Medicine
Schools of Medicine
United States
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King, Benjamin R; Samacoits, Aubin; Eisenhauer, Philip L et al. (2018) Visualization of Arenavirus RNA Species in Individual Cells by Single-Molecule Fluorescence In Situ Hybridization Suggests a Model of Cyclical Infection and Clearance during Persistence. J Virol 92:
Ziegler, Christopher M; Bruce, Emily A; Kelly, Jamie A et al. (2018) The use of novel epitope-tagged arenaviruses reveals that Rab5c-positive endosomal membranes are targeted by the LCMV matrix protein. J Gen Virol 99:187-193
Hasan, Muhammad M; Teixeira, Jose E; Huston, Christopher D (2018) Invadosome-Mediated Human Extracellular Matrix Degradation by Entamoeba histolytica. Infect Immun 86:
King, Benjamin R; Hershkowitz, Dylan; Eisenhauer, Philip L et al. (2017) A Map of the Arenavirus Nucleoprotein-Host Protein Interactome Reveals that Junín Virus Selectively Impairs the Antiviral Activity of Double-Stranded RNA-Activated Protein Kinase (PKR). J Virol 91:
Bonney, Elizabeth A; Howard, Ann; Krebs, Kendall et al. (2017) Impact of Immune Deficiency on Remodeling of Maternal Resistance Vasculature 4 Weeks Postpartum in Mice. Reprod Sci 24:514-525
King, Benjamin R; Kellner, Samuel; Eisenhauer, Philip L et al. (2017) Visualization of the lymphocytic choriomeningitis mammarenavirus (LCMV) genome reveals the early endosome as a possible site for genome replication and viral particle pre-assembly. J Gen Virol :
Bonney, Elizabeth A (2017) Alternative theories: Pregnancy and immune tolerance. J Reprod Immunol 123:65-71
Ziegler, Christopher M; Eisenhauer, Philip; Kelly, Jamie A et al. (2017) A proteomic survey of Junín virus interactions with human proteins reveals host factors required for arenavirus replication. J Virol :
Bonney, Elizabeth A; Krebs, Kendall; Saade, George et al. (2016) Differential senescence in feto-maternal tissues during mouse pregnancy. Placenta 43:26-34
Sateriale, Adam; Miller, Peter; Huston, Christopher D (2016) Knockdown of Five Genes Encoding Uncharacterized Proteins Inhibits Entamoeba histolytica Phagocytosis of Dead Host Cells. Infect Immun 84:1045-1053

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