This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Regarding AIDS: Overview: The core will focus on screening natural products with possible membership in four drug categories: opiate-like, stimulant-like, marijuana-like and depressant-like compounds. While these categories have potential therapeutic uses they are also associated with abuse potential and other negative side effects including, motor side effects, temperature dysregulation, changes in food intake, and cognitive impairments (memory and reaction time).
Our first aim i s to set up the behavioral core and validate the use of specific behavioral tests by using prototypical drugs as positive controls.
Our second aim i s to assess natural products identified by one of the center investigators. In some cases, a hypothesized mechanism of action will be identified (e.g. opiate receptors in Dr. McCurdy's project and cannabinoid receptors in Dr. Ross' project), and the behavioral test battery will focus on known functions of those receptor systems. In other cases, the hypothesized mechanism of action of a novel natural product will be unknown and promising compounds will be screened for membership in one of the four drug categories, and their behavioral side effect profile will be evaluated. Targeting appropriate compounds for specific therapeutic uses will be the focus of future research
| Mohamed, Shaymaa M M; Elokely, Khaled M; Bachkeet, Enaam Y et al. (2015) New Glycosides and Trypanocidal Metabolites from Vangueria edulis. Nat Prod Commun 10:1897-900 |
| Radwan, Mohamed M; ElSohly, Mahmoud A; El-Alfy, Abir T et al. (2015) Isolation and Pharmacological Evaluation of Minor Cannabinoids from High-Potency Cannabis sativa. J Nat Prod 78:1271-6 |
| Tabrizian, Tahmineh; Hataway, Felicia; Murray, David et al. (2015) Prolylcarboxypeptidase gene expression in the heart and kidney: Effects of obesity and diabetes. Cardiovasc Hematol Agents Med Chem 13:113-23 |
| Ahmed, Safwat A; Ross, Samir A; Slade, Desmond et al. (2015) Minor oxygenated cannabinoids from high potency Cannabis sativa L. Phytochemistry 117:194-9 |
| Gómez-Betancur, Isabel; Cortés, Natalie; Benjumea, Dora et al. (2015) Antinociceptive activity of extracts and secondary metabolites from wild growing and micropropagated plants of Renealmia alpinia. J Ethnopharmacol 165:191-7 |
| Maddineni, Sindhuri; Battu, Sunil Kumar; Morott, Joe et al. (2015) Influence of process and formulation parameters on dissolution and stability characteristics of Kollidon® VA 64 hot-melt extrudates. AAPS PharmSciTech 16:444-54 |
| Morgan, J Brian; Liu, Yang; Coothankandaswamy, Veena et al. (2015) Kalkitoxin inhibits angiogenesis, disrupts cellular hypoxic signaling, and blocks mitochondrial electron transport in tumor cells. Mar Drugs 13:1552-68 |
| Malak, Lourin G; Ibrahim, Mohamed Ali; Bishay, Daoud W et al. (2014) Antileishmanial metabolites from Geosmithia langdonii. J Nat Prod 77:1987-91 |
| Tarawneh, Amer H; León, Francisco; Ibrahim, Mohammed A et al. (2014) Flavanones from Miconia prasina. Phytochem Lett 7:130-132 |
| Chatterjee, Arindam; Cutler, Stephen J; Doerksen, Robert J et al. (2014) Discovery of thienoquinolone derivatives as selective and ATP non-competitive CDK5/p25 inhibitors by structure-based virtual screening. Bioorg Med Chem 22:6409-21 |
Showing the most recent 10 out of 134 publications
