The Neuropathology (NP) Core of this ADCC will provide for post-mortem diagnoses on patients and control subjects enrolled in the clinical core and on other well-documented AD cases and controls. The protocols used by the NP aim to be state of the art and consistent with 21st century brain banking procedures, which is essential to met the increasingly sophisticated needs of the AD research community {3922, 3921, 3920, 3919, 3918}. The tissue of the NP core is banked and distributed for research purposes as determined by the Tissue Utilization Committee, while protecting the privacy of research subjects. Part of this NP core and unchanged from the prior grant period, is a Morphometric Component performed at the Institute for Basic Research (IBR) on Staten Island. The Morphometric Component of this core is essential for the careful characterization of AD and control brain tissue in terms of the volume of different brain structures, number of neurons, glial cells, amyloid load and neurons with neurofibrillary change. This information can then be used for precise clinico-pathological correlation.
The Specific Aims of this Neuropathology Core are: 1 .To conduct thorough postmortem examinations on NYU ADCC patients (N=25-30/yr from NYU) using the NIA-Reagan Institute Working Group criteria for the diagnosis of AD. 2.To maintain a bank of unfixed frozen and fixed tissue from the ADCC control and patients with AD or other dementing neurodegenerative conditions. 3.To provide tissue from control brains, AD and other neurodegenerative conditions to AD and prion researchers within and outside this ADCC in order to augment clinical and basic research on dementia. 4.To conduct morphometric studies on AD to establish better clinical neuropathological correlation, in particular to document the progression of the earlier stages of AD pathology. 5.To conduct anatomic and pathologic correlation with in vivo and post mortem MR scans in collaboration with the Neuroimaging Core. 6.To collaborate in the research efforts of the other cores and projects of the ADCC, as well as providing advice and facilities to investigators within and outside the ADCC who seek to conduct morphometric, immunohistochemical of demented and control patients using post-mortem tissue.

Public Health Relevance

The NP core functions to provide essential neuropathological and morphometric characterization of patients who are followed in the clinical core, to allow for clinico-pathological correlations. In addition, it serves to provide tissue for numerous NIH funded AD and prion researchers. The NP core also serves as a resources for peforming studies on AD human and mouse model tissue.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG008051-23
Application #
8468477
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4)
Project Start
Project End
Budget Start
2012-05-15
Budget End
2013-04-30
Support Year
23
Fiscal Year
2012
Total Cost
$82,475
Indirect Cost
$33,596
Name
New York University
Department
Type
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Gallagher, Damien; Kiss, Alex; Lanctot, Krista L et al. (2018) Toward Prevention of Mild Cognitive Impairment in Older Adults With Depression: An Observational Study of Potentially Modifiable Risk Factors. J Clin Psychiatry 80:
Kirson, Noam Y; Scott Andrews, J; Desai, Urvi et al. (2018) Patient Characteristics and Outcomes Associated with Receiving an Earlier Versus Later Diagnosis of Probable Alzheimer's Disease. J Alzheimers Dis 61:295-307
Barnes, Josephine; Bartlett, Jonathan W; Wolk, David A et al. (2018) Disease Course Varies According to Age and Symptom Length in Alzheimer's Disease. J Alzheimers Dis 64:631-642
Adhikari, Bhim M; Jahanshad, Neda; Shukla, Dinesh et al. (2018) Heritability estimates on resting state fMRI data using ENIGMA analysis pipeline. Pac Symp Biocomput 23:307-318
Burke, Shanna L; Maramaldi, Peter; Cadet, Tamara et al. (2018) Decreasing hazards of Alzheimer's disease with the use of antidepressants: mitigating the risk of depression and apolipoprotein E. Int J Geriatr Psychiatry 33:200-211
Solesio, MarĂ­a E; Peixoto, Pablo M; Debure, Ludovic et al. (2018) Carbonic anhydrase inhibition selectively prevents amyloid ? neurovascular mitochondrial toxicity. Aging Cell :e12787
Qian, Winnie; Fischer, Corinne E; Schweizer, Tom A et al. (2018) Association Between Psychosis Phenotype and APOE Genotype on the Clinical Profiles of Alzheimer's Disease. Curr Alzheimer Res 15:187-194
Masurkar, Arjun V (2018) Towards a circuit-level understanding of hippocampal CA1 dysfunction in Alzheimer's disease across anatomical axes. J Alzheimers Dis Parkinsonism 8:
Gallagher, Damien; Kiss, Alex; Lanctot, Krista et al. (2018) Depression and Risk of Alzheimer Dementia: A Longitudinal Analysis to Determine Predictors of Increased Risk among Older Adults with Depression. Am J Geriatr Psychiatry 26:819-827
Weintraub, Sandra; Besser, Lilah; Dodge, Hiroko H et al. (2018) Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS). Alzheimer Dis Assoc Disord 32:10-17

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