The mission of the University of Pennsylvania (Penn) Alzheimer's Disease Core Center (ADCC) is to increase understanding of Alzheimer's Disease (AD) and related disorders as well as prodromal phases of dementia in the community served by Penn, foster interactions between this ADCC and ongoing research programs on AD and related disorders at Penn, stimulate the development of new research initiatives on these neurodegenerative conditions through Pilot grants and increase the quality and quantity of research overall on AD and related disorders at and beyond Penn. Substantial progress has been made in the current funding period of the Penn ADCC towards the accomplishment of these goals, and this will continue in the renewal period. Since the mechanisms leading to behavioral abnormalities and the selective degeneration of the nervous system in AD and related disorders remain poorly understood, the Penn ADCC provides a unique and cost-efficient resource for outreach, education and research that will elucidate the pathobiology of these disorders and lead to strategies for the early diagnosis, prevention and/or amelioration of AD and related disorders. ? ? To accomplish its mission, the Penn ADCC continues to support: 1) An Administrative Core (Core A) to oversee and direct the activities of the ADCC; 2) A Clinical Core (Core B) to coordinate the recruitment and continued assessment of subjects with AD, or related disorders and control subjects including women and minorities; 3) A Data Management and Biostatistics Core (Core C) to support research through effective data management and biostatistical expertise; 4) A Neuropathology Core (Core D) to establish postmortem diagnoses on subjects followed in Core B, and to obtain and bank fluids and tissues from ADCC subjects for diagnostic studies and research; 5) An Education and Information Transfer Core (Core E) to foster interest in and awareness of AD and related disorders as well other activities of the Penn ADCC, in addition to developing outreach initiatives to urban minorities in the West Philadelphia and Latino communities served by the Penn ADCC; 6) A Pilot Grant Program that stimulates novel lines of research on AD and related disorders to launch new and independently funded studies. ? ? In sum, the Penn ADCC will continue to foster research and educational efforts to increase understanding of the clinical and molecular basis of AD and related disorders, as well as the broad effects of this late-life dementia on our society. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
2P30AG010124-16
Application #
7124826
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4 (M1))
Program Officer
Phelps, Creighton H
Project Start
1997-07-15
Project End
2011-06-30
Budget Start
2006-08-01
Budget End
2007-06-30
Support Year
16
Fiscal Year
2006
Total Cost
$1,324,823
Indirect Cost
Name
University of Pennsylvania
Department
Pathology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Weintraub, Sandra; Besser, Lilah; Dodge, Hiroko H et al. (2018) Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS). Alzheimer Dis Assoc Disord 32:10-17
Largent, Emily A; Karlawish, Jason; Grill, Joshua D (2018) Study partners: essential collaborators in discovering treatments for Alzheimer's disease. Alzheimers Res Ther 10:101
Brent, Robert J (2018) Estimating the monetary benefits of medicare eligibility for reducing the symptoms of dementia. Appl Econ 50:6327-6340
Irwin, David J; McMillan, Corey T; Xie, Sharon X et al. (2018) Asymmetry of post-mortem neuropathology in behavioural-variant frontotemporal dementia. Brain 141:288-301
Gallagher, Damien; Kiss, Alex; Lanctot, Krista et al. (2018) Depression and Risk of Alzheimer Dementia: A Longitudinal Analysis to Determine Predictors of Increased Risk among Older Adults with Depression. Am J Geriatr Psychiatry 26:819-827
Bezdicek, Ondrej; ?ervenková, Markéta; Moore, Tyler M et al. (2018) Determining a Short Form Montreal Cognitive Assessment (s-MoCA) Czech Version: Validity in Mild Cognitive Impairment Parkinson's Disease and Cross-Cultural Comparison. Assessment :1073191118778896
Phillips, Jeffrey S; Da Re, Fulvio; Dratch, Laynie et al. (2018) Neocortical origin and progression of gray matter atrophy in nonamnestic Alzheimer's disease. Neurobiol Aging 63:75-87
Haaksma, Miriam L; Calderón-Larrañaga, Amaia; Olde Rikkert, Marcel G M et al. (2018) Cognitive and functional progression in Alzheimer disease: A prediction model of latent classes. Int J Geriatr Psychiatry 33:1057-1064
Racine, Annie M; Brickhouse, Michael; Wolk, David A et al. (2018) The personalized Alzheimer's disease cortical thickness index predicts likely pathology and clinical progression in mild cognitive impairment. Alzheimers Dement (Amst) 10:301-310
Wilmoth, Kristin; LoBue, Christian; Clem, Matthew A et al. (2018) Consistency of traumatic brain injury reporting in older adults with and without cognitive impairment. Clin Neuropsychol 32:524-529

Showing the most recent 10 out of 720 publications