The purpose of the Boston University Alzheimer's Disease Center (BU ADC) is to promote research on Alzheimer's Disease (AD) at BU and throughout the country by providing information and materials from well characterized patient, control and caregiver populations drawn from the ambulatory and late-stage suburban population at the Bedord VA Medical Center and the racially, ethnically, and culturally diverse poor urban Registry of the Clinical Core are assessed annually with a standardized neurological examination and neuropsychological test battery. Blood is obtained and stored for molecular genetic studies. A detailed family neuropsychological test battery. Blood is obtained and stored for molecular genetic studies. A detailed family history is obtained and a separate Caregiver Registry collects annual standardized information on family and professional caregivers. This information is entered into a database for longitudinal comparisons and correlation with the progression of AD and its impact on caregivers. Subjects, data and blood/DNA are made available to qualified researchers to stimulate new research in AD and normal aging. The Neuropathology Core establishes accurate pathological diagnoses, rigorous documentation and quantitation of neuropathological changes, harvests endothelial cells, and collects, stores and disburses post-mortem tissue. The Education and Information Transfer Core supports the development of physicians and other professional caregivers to improve clinical and research skills related to AD and provide outreach programs to increase caregivers' and the lay public's knowledge of AD. Nationally, this Core collaborates with other ADCs, ADEAR Center, Alzheimer Association and other groups to advance AD care, education, and research. The Murine Breeding and Molecular Genetics Core maintains a transgenic mouse colony as well as several colonies of mice with AD-related phenotypes including: 1) increased or decreased susceptibility to oxidative injury 2) Calreticulin Knockout mice 3) over expression or under expression of APOE. This comprehensive breeding facility is a unique resource for investigators. The BU ADC funds pilot projects to promote new AD research and fosters the development of new AD investigators. These multiple activities are coordinated by the Administrative Core. The BU ADC has greatly strengthened and expanded AD research at BU and has facilitated the involvement of African Americans in aging and dementia research. The BU ADC has promoted and supported AD research on a comprehensive range of topics including pathogenesis, animal models, neuropathology, genetic and environmental risk and protective factors, late-stage dementia, and the impact of disease burden on caregivers and society.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG013846-10
Application #
6921876
Study Section
Special Emphasis Panel (ZAG1-PCR-5 (M1))
Program Officer
Phelps, Creighton H
Project Start
1996-07-01
Project End
2006-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
10
Fiscal Year
2005
Total Cost
$1,185,888
Indirect Cost
Name
Boston University
Department
Neurology
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Haaksma, Miriam L; Calderón-Larrañaga, Amaia; Olde Rikkert, Marcel G M et al. (2018) Cognitive and functional progression in Alzheimer disease: A prediction model of latent classes. Int J Geriatr Psychiatry 33:1057-1064
Wilmoth, Kristin; LoBue, Christian; Clem, Matthew A et al. (2018) Consistency of traumatic brain injury reporting in older adults with and without cognitive impairment. Clin Neuropsychol 32:524-529
Ting, Simon Kang Seng; Foo, Heidi; Chia, Pei Shi et al. (2018) Dyslexic Characteristics of Chinese-Speaking Semantic Variant of Primary Progressive Aphasia. J Neuropsychiatry Clin Neurosci 30:31-37
Ikezu, Tsuneya; Chen, Cidi; DeLeo, Annina M et al. (2018) Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans. J Neuroimmune Pharmacol 13:254-264
Ramsey, Christine M; Gnjidic, Danijela; Agogo, George O et al. (2018) Longitudinal patterns of potentially inappropriate medication use following incident dementia diagnosis. Alzheimers Dement (N Y) 4:1-10
Alosco, Michael L; Tripodis, Yorghos; Fritts, Nathan G et al. (2018) Cerebrospinal fluid tau, A?, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration. Alzheimers Dement 14:1159-1170
Hadjichrysanthou, Christoforos; McRae-McKee, Kevin; Evans, Stephanie et al. (2018) Potential Factors Associated with Cognitive Improvement of Individuals Diagnosed with Mild Cognitive Impairment or Dementia in Longitudinal Studies. J Alzheimers Dis 66:587-600
Hanfelt, John J; Peng, Limin; Goldstein, Felicia C et al. (2018) Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center. Neurobiol Dis 117:62-71
Burke, Shanna L; Hu, Tianyan; Fava, Nicole M et al. (2018) Sex differences in the development of mild cognitive impairment and probable Alzheimer's disease as predicted by hippocampal volume or white matter hyperintensities. J Women Aging :1-25
Guan, Yue; Roter, Debra L; Wolff, Jennifer L et al. (2018) The impact of genetic counselors' use of facilitative strategies on cognitive and emotional processing of genetic risk disclosure for Alzheimer's disease. Patient Educ Couns 101:817-823

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